Angiogenesis modulates adipogenesis and obesity

Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult...

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Bibliographic Details
Published in:The Journal of clinical investigation 2007-09, Vol.117 (9), p.2362-2368
Main Author: Cao, Yihai
Format: Article
Language:English
Subjects:
Adipocytes
Adipocytes - drug effects
Adipocytes - metabolism
Adipogenesis
Angiogenesis
Angiogenesis Inducing Agents - pharmacology
Animals
Biomedical research
Body fat
Cardiovascular disease
Cell Communication
Endothelial Cells - metabolism
Genetic aspects
Humans
Industrialized nations
Neovascularization
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
Obesity
Obesity - metabolism
Obesity - pathology
Obesity - therapy
Observations
Science in Medicine
Stroke
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Summary:Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult life. Activated adipocytes produce multiple angiogenic factors including leptin, angiopoietins, HGF, GM-CSF, VEGF, FGF-2, and TGF-beta, which either alone or collectively stimulate neovascularization during fat mass expansion. Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI32239