Does chemotherapy prior to liver resection increase the potential for cure in patients with metastatic colorectal cancer? A report from the European Colorectal Metastases Treatment Group

Abstract Liver resection offers the only chance of cure for patients with advanced colorectal cancer (CRC). Typically, the 5-year survival rates following liver resection range from 25% to 40%. Unfortunately, approximately 85% of patients with stage IV CRC have liver disease which is considered unre...

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Bibliographic Details
Published in:European journal of cancer (1990) 2007-09, Vol.43 (14), p.2037-2045
Main Authors: Nordlinger, Bernard, Van Cutsem, Eric, Rougier, Philippe, Köhne, Claus-Henning, Ychou, Marc, Sobrero, Alberto, Adam, Rene, Arvidsson, Dag, Carrato, Alfredo, Georgoulias, Vassilis, Giuliante, Felice, Glimelius, Bengt, Golling, Markus, Gruenberger, Thomas, Tabernero, Josep, Wasan, Harpreet, Poston, Graeme
Format: Article
Language:English
Subjects:
5-Fluorouracil
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Chemotherapy, Adjuvant
Colorectal cancer
Colorectal Neoplasms
Hematology, Oncology and Palliative Medicine
Hepatectomy - methods
Humans
Irinotecan
Liver metastases
Liver Neoplasms - drug therapy
Liver Neoplasms - secondary
Liver Neoplasms - surgery
Liver Neoplasms/drug therapy/secondary/surgery
Liver resection
Medical sciences
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Neoadjuvant
Oxaliplatin
Perioperative chemotherapy
Pharmacology. Drug treatments
Preoperative Care - methods
Targeted agents
Tumors
Unresectable
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Summary:Abstract Liver resection offers the only chance of cure for patients with advanced colorectal cancer (CRC). Typically, the 5-year survival rates following liver resection range from 25% to 40%. Unfortunately, approximately 85% of patients with stage IV CRC have liver disease which is considered unresectable at presentation. However, the rapid expansion in the use of improved combination therapy regimens has increased the percentage of patients eligible for potentially curative surgery. Despite this, the selection criteria for patients potentially suitable for resection are not well documented and patient management by multidisciplinary teams, although essential, is still evolving. The goal of the European Colorectal Metastases Treatment Group is to establish pan-European guidelines for the treatment of patients with CRC liver metastases that can be adopted more widely by established treatment centres and to develop more accurate staging systems and evaluation criteria.
ISSN:0959-8049
1879-0852
1879-0852
DOI:10.1016/j.ejca.2007.07.017