A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus

• Published in: Tissue antigens 2007-11, Vol.70 (5), p.412-414
• Main Authors: Linga-Reddy, M. V. Prasad, Gunnarsson, I., Svenungsson, E., Sturfelt, G., Jönsen, A., Truedsson, L., Nordmark, G., Rönnblom, L., Alarcón-Riquelme, M. E.
• Format: Article
• Language: English
• Subjects: Alleles; Basic Medicine; Case-Control Studies; class II transactivator; Clinical Medicine; Female; Genetic Predisposition to Disease; Genotype; Histocompatibility Antigens Class II; Humans; Immunologi inom det medicinska området; Immunology in the medical area; Klinisk medicin; Lupus Erythematosus; Lupus Erythematosus, Systemic - genetics; major histocompatibility complex class II; major histocompatibility complex class II transactivator; Male; Medical and Health Sciences; MEDICIN; Medicin och hälsovetenskap; MEDICINE; Medicinska och farmaceutiska grundvetenskaper; Microbiology in the medical area; Mikrobiologi inom det medicinska området; Multiple Sclerosis - genetics; Myocardial Infarction - genetics; Nuclear Proteins - genetics; Polymorphism; Polymorphism, Single Nucleotide; Reumatologi och inflammation; Rheumatology and Autoimmunity; Single Nucleotide; Sweden; systemic lupus erythematosus; Systemic/genetics; Trans-Activators - genetics; transactivator
• ISSN: 0001-2815; 1399-0039; 1399-0039
• DOI: 10.1111/j.1399-0039.2007.00920.x

Single‐nucleotide polymorphisms (SNPs) in the major histocompatibility complex class II transactivator (MHC2TA) gene encoding the class II transactivator have been associated with multiple sclerosis, rheumatoid arthritis, and myocardial infarction in the Swedish population. We used a case–control approach to investigate the prevalence of a relevant variant in Swedish systemic lupus erythematosus (SLE) cohorts to determine whether SLE shares the same MHC2TA susceptibility allele as the other diseases. No differences were observed between cases and control subjects at either the allele or genotype levels. Furthermore, no significant correlations were found when comparing different clinical and serological SLE phenotypes. This particular polymorphism rs3087456 of the MHC2TA gene does not appear to influence genetic susceptibility to SLE in the Swedish population. We conclude that our data support neither allelic nor genotype association between the MHC2TA SNP and SLE.