Development and descent of the testis in relation to cryptorchidism

The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin‐like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the a...

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Bibliographic Details
Published in:Acta Paediatrica 2007-05, Vol.96 (5), p.622-627
Main Authors: Virtanen, Helena E, Cortes, Dina, Rajpert-De Meyts, Ewa, Ritzén, E Martin, Nordenskjöld, Agneta, Skakkebaek, Niels E, Toppari, Jorma
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Differentiation - physiology
Child
Cryptorchidism
Cryptorchidism - embryology
Cryptorchidism - genetics
Cryptorchidism - pathology
Cryptorchidism - physiopathology
General aspects
Gynecology. Andrology. Obstetrics
Histology
Humans
Infant
Insulin - physiology
Leydig Cells - cytology
Leydig Cells - physiology
Male
Male genital diseases
Medical sciences
Medicin och hälsovetenskap
Models, Animal
Non tumoral diseases
Proteins - physiology
Testicular descent
Testis - embryology
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Summary:The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin‐like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis‐derived hormones, cryptorchidism may reflect a functional defect of the testis.
ISSN:0803-5253
1651-2227
DOI:10.1111/j.1651-2227.2007.00244.x