Does treatment of newly diagnosed idiopathic thrombocytopenic purpura reduce morbidity?

Aim: To explore whether early treatment of children with idiopathic thrombocytopenic purpura (ITP) with immunoglobulin and/or corticosteroids reduces subsequent morbidity. Methods: Centres participating in a Nordic ITP study were divided according to whether they had treated more than 2/3, from 1/3...

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Bibliographic Details
Published in:Archives of disease in childhood 2007-08, Vol.92 (8), p.704-707
Main Authors: Treutiger, Iris, Rajantie, Jukka, Zeller, Bernward, Henter, Jan-Inge, Elinder, Göran, Rosthøj, Steen
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Biological and medical sciences
Blood platelets
Blood products
Bone marrow
Care and treatment
Child, Preschool
Corticoids
Corticosteroid drugs
corticosteroid therapy
Corticosteroids
Female
Finland - epidemiology
General aspects
Hematologic and hematopoietic diseases
Hemorrhage - etiology
Humans
Iceland - epidemiology
idiopathic thrombocytopenic purpura
immunoglobulin therapy
Immunoglobulins
Immunoglobulins, Intravenous - therapeutic use
Individualized Transition Plans
Infant
Infant, Newborn
intravenous immunoglobulin
Intravenous immunoglobulins
ITP
IVIG
Male
Medical sciences
Medicin och hälsovetenskap
Miscellaneous
Morbidity
Original
Patient outcomes
Platelet Count
Platelet diseases and coagulopathies
Prevention and actions
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
Purpura
Purpura, Thrombocytopenic, Idiopathic - complications
Purpura, Thrombocytopenic, Idiopathic - drug therapy
Purpura, Thrombocytopenic, Idiopathic - epidemiology
Risk factors
Scandinavian and Nordic Countries - epidemiology
Statistics
Steroids
Thrombocytopenia
Thrombocytopenic purpura
Treatment Outcome
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Summary:Aim: To explore whether early treatment of children with idiopathic thrombocytopenic purpura (ITP) with immunoglobulin and/or corticosteroids reduces subsequent morbidity. Methods: Centres participating in a Nordic ITP study were divided according to whether they had treated more than 2/3, from 1/3 to 2/3, or less than 1/3 children within 14 days of diagnosis. The course of disease from 15 days to 6 months after diagnosis was compared for children managed at the three centre categories. The comparison was restricted to children in whom at least one platelet count 20×109/l in 67%, 67% and 52% (p150×109/l in 38%, 29% and 29% (p
ISSN:0003-9888
1468-2044
1468-2044
DOI:10.1136/adc.2006.098442