Risk of second non-hematological malignancies among 376,825 breast cancer survivors

Breast cancer survivors are at increased risk of treatment-related second cancers. This study is the first to examine risk 30 or more years after diagnosis and to present absolute risks of second cancer which accounts for competing mortality. We identified 23,158 second non-hematological malignancie...

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Bibliographic Details
Published in:Breast cancer research and treatment 2007-12, Vol.106 (3), p.439-451
Main Authors: BROWN, Linda Morris, CHEN, Bingshu E, JOENSUU, Heikki, FOSSA, Sophie D, TRAVIS, Lois B, PFEIFFER, Ruth M, SCHAIRER, Catherine, HALL, Per, STORM, Hans, PUKKALA, Eero, LANGMARK, Froydis, KAIJSER, Magnus, ANDERSSON, Michael
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Breast cancer
Breast Neoplasms - complications
Breast Neoplasms - radiotherapy
Cancer
Cancer research
Cancer therapies
Cohort Studies
Female
Gynecology. Andrology. Obstetrics
Humans
Incidence
Mammary gland diseases
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Mortality
Neoplasms, Second Primary - etiology
Risk
Risk factors
Survivor
Survivors
Tumors
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Summary:Breast cancer survivors are at increased risk of treatment-related second cancers. This study is the first to examine risk 30 or more years after diagnosis and to present absolute risks of second cancer which accounts for competing mortality. We identified 23,158 second non-hematological malignancies excluding breast in a population-based cohort of 376,825 one-year survivors of breast cancer diagnosed from 1943 to 2002 and reported to four Scandinavian cancer registries. We calculated standardized incidence ratios (SIR) and utilized a competing-risk model to calculate absolute risk of developing second cancers. The overall SIR for second cancers was 1.15 (95% confidence interval [CI] = 1.14-1.17). The SIR for potentially radiotherapy-associated cancers 30 or more years after breast cancer diagnosis was 2.19 (95% CI = 1.87-2.55). However, the largest SIRs were observed for women aged
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-007-9509-8