Longitudinal scintigraphic study of parotid and submandibular gland function after total body irradiation in children and adolescents

• Published in: International journal of paediatric dentistry 2007-01, Vol.17 (1), p.34-40
• Main Authors: BÅGESUND, MATS, RICHTER, SVEN, RINGDÉN, OLLE, DAHLLÖF, GÖRAN
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Child; Cyclophosphamide - therapeutic use; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; MEDICIN; Medicin och hälsovetenskap; MEDICINE; Myeloablative Agonists - therapeutic use; Parotid Gland - diagnostic imaging; Parotid Gland - drug effects; Parotid Gland - radiation effects; Parotid Gland - secretion; Radionuclide Imaging; Radiopharmaceuticals; Salivation - drug effects; Salivation - radiation effects; Secretory Rate - drug effects; Secretory Rate - radiation effects; Stem Cell Transplantation; Submandibular Gland - diagnostic imaging; Submandibular Gland - drug effects; Submandibular Gland - radiation effects; Submandibular Gland - secretion; Technetium; Transplantation Conditioning; Whole-Body Irradiation
• ISSN: 0960-7439; 1365-263X; 1365-263X
• DOI: 10.1111/j.1365-263X.2006.00786.x

Objective.  Total body irradiation (TBI) and cyclophosphamide (CY) during allogeneic stem cell transplantation (ASCT) cause salivary gland dysfunction in children. The aim of this investigation was to study the scintigraphic functional changes over time of the parotid and submandibular glands in children and young adults one year after treatment with CY and TBI at ASCT. Methods.  Salivary gland scintigraphy (SGS) was performed before ASCT, and 3–6 months and 12 months after ASCT. The three male patients who fulfilled the scintigraphic study had a mean age (± SD) of 17.3 ± 9.8 years at ASCT. Results.  The parotid secretion capacity (SPar) was 83.5 ± 3.2% before ASCT and 48.5 ± 25.8% during the next 3–6 months (P