Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia

Recent evidence suggests that chronic lymphocytic leukemia (CLL) might occur following a response to an infectious agent. We conducted a population-based study including 4249 CLL patients diagnosed in Denmark from 1977 to 1997 and 15 690 frequency-matched controls to quantify risk of CLL following v...

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Bibliographic Details
Published in:Blood 2007-03, Vol.109 (5), p.2198-2201
Main Authors: Landgren, Ola, Rapkin, Joshua S., Caporaso, Neil E., Mellemkjaer, Lene, Gridley, Gloria, Goldin, Lynn R., Engels, Eric A.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Female
Hematologic and hematopoietic diseases
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - classification
Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology
Leukemia, Lymphocytic, Chronic, B-Cell - etiology
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Neoplasia
Neoplasm Staging
Respiratory Tract Infections - complications
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - immunology
Respiratory Tract Infections - pathology
Risk Factors
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Summary:Recent evidence suggests that chronic lymphocytic leukemia (CLL) might occur following a response to an infectious agent. We conducted a population-based study including 4249 CLL patients diagnosed in Denmark from 1977 to 1997 and 15 690 frequency-matched controls to quantify risk of CLL following various airway infections. Through data linkage we gathered information on hospital inpatient/outpatient discharges that listed infections present at least 1 year prior to CLL. Using logistic regression, we calculated odds ratios (ORs) and 95% confidence intervals (CIs). Personal history of pneumonia was associated with significantly increased CLL risk (OR = 1.4; 1.2-1.8); risk was restricted to 1 to 4.99 years prior to CLL diagnosis (OR = 1.6; 1.2-2.0). Individuals with 3 or more prior pneumonia events had a significant 2.5-fold (1.1-5.6) elevated CLL risk, and risk increased with the number of pneumonia episodes (Ptrend < .001). None of 9 other respiratory-tract infections was significantly associated with CLL risk. Pneumonia might be a potential CLL trigger or it could represent premalignant immune disruption preceding CLL.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2006-08-044008