Clinical significance of corpus callosum atrophy in a mixed elderly population

Abstract Corpus callosum (CC) is the main tract connecting the hemispheres, but the clinical significance of CC atrophy is poorly understood. The aim of this work was to investigate clinical and functional correlates of CC atrophy in subjects with age-related white matter changes (ARWMC). In 569 eld...

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Bibliographic Details
Published in:Neurobiology of aging 2007-06, Vol.28 (6), p.955-963
Main Authors: Ryberg, C, Rostrup, E, Stegmann, M.B, Barkhof, F, Scheltens, P, van Straaten, E.C.W, Fazekas, F, Schmidt, R, Ferro, J.M, Baezner, H, Erkinjuntti, T, Jokinen, H, Wahlund, L.-O, O’Brien, J, Basile, A.M, Pantoni, L, Inzitari, D, Waldemar, G
Format: Article
Language:English
Subjects:
Age Factors
Age-related white matter changes
Aged
Aged, 80 and over
Aging - pathology
Atrophy
Cognition
Cognition Disorders - etiology
Cognition Disorders - pathology
Corpus callosum
Corpus Callosum - pathology
Corpus Callosum - physiopathology
Cross-Sectional Studies
Depression - etiology
Disabled Persons
Elderly
Female
Gait - physiology
Humans
Internal Medicine
LADIS
Leukoaraiosis
Leukoaraiosis - pathology
Longitudinal Studies
Magnetic Resonance Imaging - methods
Male
Medicin och hälsovetenskap
Middle Aged
Motor function
MRI
Neurology
Neuropsychological Tests
Psychomotor Performance - physiology
Sex Factors
Tomography Scanners, X-Ray Computed
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Summary:Abstract Corpus callosum (CC) is the main tract connecting the hemispheres, but the clinical significance of CC atrophy is poorly understood. The aim of this work was to investigate clinical and functional correlates of CC atrophy in subjects with age-related white matter changes (ARWMC). In 569 elderly subjects with ARWMC from the Leukoaraiosis And DISability (LADIS) study, the CC was segmented on the normalised mid-sagittal magnetic resonance imaging (MRI) slice and subdivided into five regions. Correlations between the CC areas and subjective memory complaints, mini mental state examination (MMSE) score, history of depression, geriatric depression scale (GDS) score, subjective gait difficulty, history of falls, walking speed, and total score on the short physical performance battery (SPPB) were analyzed. Significant correlations between CC atrophy and MMSE, SPPB, and walking speed were identified, and the CC areas were smaller in subjects with subjective gait difficulty. The correlations remained significant after correction for ARWMC grade. In conclusion, CC atrophy was independently associated with impaired global cognitive and motor function in subjects with ARWMC.
ISSN:0197-4580
1558-1497
1558-1497
DOI:10.1016/j.neurobiolaging.2006.04.008