Multiple pathways of cytochrome c release from mitochondria in apoptosis

Release of cytochrome c from mitochondria is a key initiative step in the apoptotic process, although the mechanisms regulating permeabilization of the outer mitochondrial membrane and the release of intermembrane space proteins remain controversial. Here, we discuss possible scenarios of the outer...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2006-05, Vol.1757 (5), p.639-647
Main Authors: Gogvadze, Vladimir, Orrenius, Sten, Zhivotovsky, Boris
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Bcl-2 family
Caspase 2
Caspases - metabolism
Cytochrome c
Cytochromes c - metabolism
Medicin och hälsovetenskap
Mitochondria
Mitochondria - metabolism
Mitochondrial Membranes - metabolism
Permeability
Permeability transition
Proto-Oncogene Proteins c-bcl-2 - metabolism
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Summary:Release of cytochrome c from mitochondria is a key initiative step in the apoptotic process, although the mechanisms regulating permeabilization of the outer mitochondrial membrane and the release of intermembrane space proteins remain controversial. Here, we discuss possible scenarios of the outer membrane permeabilization. The mechanisms by which the intermembrane space proteins are released from mitochondria depend presumably on cell type and on the nature of the apoptotic stimulus. The variety of mechanisms that can lead to outer membrane permeabilization might explain diversities in the response of mitochondria to numerous apoptotic stimuli in different types of cells.
ISSN:0005-2728
0006-3002
1879-2650
DOI:10.1016/j.bbabio.2006.03.016