Analysis of binary traits: testing association in the presence of linkage

Most methods for testing association in the presence of linkage, using family-based studies, have been developed for continuous traits. FBAT (family-based association tests) is one of few methods appropriate for discrete outcomes. In this article we describe a new test of association in the presence...

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Bibliographic Details
Published in:BMC genetics 2005-12, Vol.6 Suppl 1 (S1), p.S92-S92, Article S92
Main Authors: Jonasdottir, Gudrun, Palmgren, Juni, Humphreys, Keith
Format: Article
Language:English
Subjects:
Genetic Linkage
Genetic Predisposition to Disease
Genetic Testing
Humans
Medicin och hälsovetenskap
Proceedings
Quantitative Trait, Heritable
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Summary:Most methods for testing association in the presence of linkage, using family-based studies, have been developed for continuous traits. FBAT (family-based association tests) is one of few methods appropriate for discrete outcomes. In this article we describe a new test of association in the presence of linkage for binary traits. We use a gamma random effects model in which association and linkage are modelled as fixed effects and random effects, respectively. We have compared the gamma random effects model to an FBAT and a generalized estimating equation-based alternative, using two regions in the Genetic Analysis Workshop 14 simulated data. One of these regions contained haplotypes associated with disease, and the other did not.
ISSN:1471-2156
1471-2156
DOI:10.1186/1471-2156-6-S1-S92