Release of mitochondrial DNA fragments from brain mitochondria of irradiated mice

Recently, we demonstrated that the release of mtDNA fragments from mitochondria occurs as a result of the opening of a non-specific pore in the inner mitochondrial membrane. Here, we show that irradiation of mice stimulates the appearance of mtDNA fragments in the cytosolic fractions of the brain. T...

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Bibliographic Details
Published in:Mitochondrion 2006-02, Vol.6 (1), p.43-47
Main Authors: Patrushev, Maxim, Kasymov, Vitaliy, Patrusheva, Valeria, Ushakova, Tatiana, Gogvadze, Vladimir, Gaziev, Azhub I
Format: Article
Language:English
Subjects:
Animals
Brain - radiation effects
Brain Chemistry
Cytosol - chemistry
DNA, Mitochondrial - analysis
DNA, Mitochondrial - radiation effects
Gamma Rays
Male
Medicin och hälsovetenskap
Mice
Mice, Inbred BALB C
Mitochondria - genetics
Mitochondria - radiation effects
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Summary:Recently, we demonstrated that the release of mtDNA fragments from mitochondria occurs as a result of the opening of a non-specific pore in the inner mitochondrial membrane. Here, we show that irradiation of mice stimulates the appearance of mtDNA fragments in the cytosolic fractions of the brain. The fragments of mtDNA were found as early as 1h after irradiation, when no observable alteration of mitochondrial functioning occurred. The involvement of mitochondrial permeability transition in this process is discussed.
ISSN:1567-7249
DOI:10.1016/j.mito.2005.12.001