Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease

. Apoptosis is a highly regulated process of cell deletion and plays a fundamental role in the maintenance of tissue homeostasis in the adult organism. Numerous studies in recent years have revealed that apoptosis is a constitutive suicide programme expressed in most, if not all cells, and can be tr...

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Bibliographic Details
Published in:Journal of internal medicine 2005-12, Vol.258 (6), p.479-517
Main Authors: FADEEL, B., ORRENIUS, S.
Format: Article
Language:English
Subjects:
Adult
Animals
apoptosis
Apoptosis - physiology
autoimmune disease
Autoimmune Diseases - physiopathology
Biological and medical sciences
cancer
Caspase Inhibitors
Caspases - metabolism
Cell Survival - physiology
Disease
General aspects
Heart Diseases - physiopathology
Homeostasis - physiology
Humans
inflammation
Inflammation - physiopathology
ischaemia/reperfusion
Medical sciences
Medicin och hälsovetenskap
Mitochondria - physiology
Neoplasms - physiopathology
neurodegeneration
Neurodegenerative Diseases - physiopathology
programmed cell clearance
Signal Transduction - physiology
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Summary:. Apoptosis is a highly regulated process of cell deletion and plays a fundamental role in the maintenance of tissue homeostasis in the adult organism. Numerous studies in recent years have revealed that apoptosis is a constitutive suicide programme expressed in most, if not all cells, and can be triggered by a variety of extrinsic and intrinsic signals. Many human diseases can be attributed directly or indirectly to a derangement of apoptosis, resulting in either cell accumulation, in which cell eradication or cell turnover is impaired, or cell loss, in which the apoptotic programme is inadvertently triggered. In addition, defective macrophage engulfment and degradation of cell corpses may also contribute to a dysregulation of tissue homeostasis. An increased understanding of the signalling pathways that govern the execution of apoptosis and the subsequent clearance of dying cells may thus yield novel targets for therapeutic intervention in a wide range of human maladies.
ISSN:0954-6820
1365-2796
DOI:10.1111/j.1365-2796.2005.01570.x