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Medication Use and Risk of Non-Hodgkin's Lymphoma

Conflicting results from previous epidemiologic studies shed little light on whether medication use is associated with risk of non-Hodgkin's lymphoma (NHL). To investigate this question, the authors conducted a population-based case-control study in Denmark and Sweden from 1999 to 2002, includi...

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Bibliographic Details
Published in:American journal of epidemiology 2005-11, Vol.162 (10), p.965-974
Main Authors: Chang, Ellen T., Smedby, Karin Ekström, Hjalgrim, Henrik, Schöllkopf, Claudia, Porwit-MacDonald, Anna, Sundström, Christer, Tani, Edneia, d'Amore, Francesco, Melbye, Mads, Adami, Hans-Olov, Glimelius, Bengt
Format: Article
Language:English
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Summary:Conflicting results from previous epidemiologic studies shed little light on whether medication use is associated with risk of non-Hodgkin's lymphoma (NHL). To investigate this question, the authors conducted a population-based case-control study in Denmark and Sweden from 1999 to 2002, including 3,055 incident NHL cases and 3,187 controls. Participants reported their past use of medications and history of particular medical conditions. Unconditional logistic regression was used to estimate multivariate odds ratios and 95% confidence intervals for the associations between medication use and risk of NHL; all statistical tests were two sided. Use of antibiotics more than 10 times during adulthood was positively associated with risk of NHL and most major NHL subtypes; when users were compared with nonusers, the odds ratio for NHL was 1.8 (95% confidence interval: 1.4, 2.3); ptrend for total antibiotic use
ISSN:0002-9262
1476-6256
1476-6256
DOI:10.1093/aje/kwi311