IgE-binding peptides coupled to a commercial matrix as a diagnostic instrument for persistent cow's milk allergy

In our previous studies, we characterized the sequential IgE-binding epitopes for the major cow's milk allergens.4-7 Observed differences between younger children who are likely to outgrow their allergy and older patients with persistent cow's milk allergy suggested that epitope specificit...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2005-09, Vol.116 (3), p.704-705
Main Authors: Beyer, Kirsten, Jarvinen, Kirsi-Marjut, Bardina, Ludmilla, Mishoe, Michelle, Turjanmaa, Kristiina, Niggemann, Bodo, Ahlstedt, Staffan, Venemalm, Lennart, Sampson, Hugh A.
Format: Article
Language:English
Subjects:
Adult
Age
Allergies
Caseins - chemistry
Caseins - immunology
Child
Child, Preschool
Epitopes
Female
Food allergies
Humans
Immunoglobulin E - blood
Male
Medicin och hälsovetenskap
Milk
Milk Hypersensitivity - diagnosis
Milk Hypersensitivity - immunology
Peptides
Peptides - immunology
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Summary:In our previous studies, we characterized the sequential IgE-binding epitopes for the major cow's milk allergens.4-7 Observed differences between younger children who are likely to outgrow their allergy and older patients with persistent cow's milk allergy suggested that epitope specificity of IgE antibody responses might predict the clinical outcome of CMA.4 Using SPOTs-membrane technology and sera from 10 patients with persistent and 10 patients with transient CMA, we identified informative IgE-binding epitopes that were not recognized by any of the patients with transient CMA but showed binding by most of the patients with persistent allergy.8 The current study was performed to confirm the relevance of these informative epitopes in a larger study population. [...]74 patients with challenge-proven CMA were included in the study.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2005.05.007