Influence of cigarette smoking on melatonin levels in man

Polycyclic aromatic hydrocarbons in cigarette smoke induce cytochrome P450(CYP)1A2, which is involved in the hepatic metabolism of melatonin (MT). This suggests that habitual smokers may have low serum MT levels during smoking compared with a non-smoking period. We decided to investigate whether thi...

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Bibliographic Details
Published in:European journal of clinical pharmacology 2005-05, Vol.61 (3), p.197-201
Main Authors: URSING, Carina, VON BAHR, Christer, BRISMAR, Kerstin, RÖJDMARK, Sven
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Antioxidants - administration & dosage
Antioxidants - pharmacokinetics
Area Under Curve
Biological and medical sciences
Circadian Rhythm
Cotinine - blood
Female
Humans
Male
Medical sciences
Melatonin - administration & dosage
Melatonin - blood
Melatonin - pharmacokinetics
Pharmacology. Drug treatments
Smoking - physiopathology
Smoking Cessation
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Summary:Polycyclic aromatic hydrocarbons in cigarette smoke induce cytochrome P450(CYP)1A2, which is involved in the hepatic metabolism of melatonin (MT). This suggests that habitual smokers may have low serum MT levels during smoking compared with a non-smoking period. We decided to investigate whether this suggestion is correct. Eight habitual smokers were tested on two occasions. They had smoked prior to the first occasion but had not smoked for 7 days prior to the second. Each test was divided into two parts. The first part spanned the night between 2000 hours and 0800 hours. Venous blood samples were collected every second hour during this period for analysis of endogenous serum MT. The second part was performed the subsequent day. At 0930 hours, 25 mg MT was ingested orally, and blood samples for exogenous serum MT analysis were collected every hour between 1000 hours and 1600 hours. Endogenous and exogenous areas under the serum MT-time curve (MT-AUCs) were calculated. Endogenous serum MT-AUCs were similar during the two periods. Oral administration of MT induced supraphysiological levels of serum MT. Moreover, exogenous serum MT-AUCs were significantly smaller before than after smoking abstinence (7.34+/-1.85 versus 21.07+/-7.28 nmol/lxh; P
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-005-0908-7