Self-rated health is related to levels of circulating cytokines

Self-rated health is a powerful and independent predictor of long-term health, but its biological basis is unknown. Because factors associated with poor self-rated health (eg, pain, daily discomforts, and low energy and fitness) resemble symptoms of a generalized cytokine-induced sickness response,...

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Bibliographic Details
Published in:Psychosomatic medicine 2004-07, Vol.66 (4), p.559-563
Main Authors: Lekander, Mats, Elofsson, Stig, Neve, Ing-Marie, Hansson, Lars-Olof, Undén, Anna-Lena
Format: Article
Language:English
Subjects:
Adult
Aged
Cytokines
Cytokines - blood
Enzyme-Linked Immunosorbent Assay
Female
Health
Health Status
Health Surveys
Humans
Interleukin-1 - blood
Interleukin-6 - blood
Male
Medicin och hälsovetenskap
Middle Aged
Perceptions
Sex Factors
Surveys and Questionnaires
Tumor Necrosis Factor-alpha - analysis
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Summary:Self-rated health is a powerful and independent predictor of long-term health, but its biological basis is unknown. Because factors associated with poor self-rated health (eg, pain, daily discomforts, and low energy and fitness) resemble symptoms of a generalized cytokine-induced sickness response, we examined the relationship between circulating cytokines and self-rated health. In 265 consecutive primary health care patients (174 women and 91 men), we examined self-rated and physician-rated health, circulating levels of interleukin (IL)-1beta, IL-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor (TNF)-alpha as determined from plasma samples using high-sensitivity enzyme-linked immunoassay. Self-rated health correlated with levels of IL-1beta (r = 0.27; p
ISSN:0033-3174
1534-7796
1534-7796
DOI:10.1097/01.psy.0000130491.95823.94