The importance of the level of metronidazole resistance for the success of Helicobacter pylori eradication

Summary Aims : To evaluate the role of antibiotic susceptibility for the treatment outcome of proton pump inhibitor‐dependent and independent Helicobacter pylori eradication regimens. Methods : In a placebo‐controlled clinical study of peptic ulcer patients with H. pylori infection, patients were ra...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2004-06, Vol.19 (12), p.1315-1321
Main Authors: Wheeldon, T.‐U., Granström, M., Hoang, T. T. H., Phuncarg, D. C., Nilsson, L. E., Sörberg, M.
Format: Article
Language:English
Subjects:
2-Pyridinylmethylsulfinylbenzimidazoles
Anti-Bacterial Agents - therapeutic use
Anti-Ulcer Agents - therapeutic use
Biological and medical sciences
Clarithromycin - therapeutic use
Digestive system
Drug Administration Schedule
Drug Resistance, Bacterial
Drug Therapy, Combination
Gastroenterology. Liver. Pancreas. Abdomen
Helicobacter Infections - complications
Helicobacter Infections - drug therapy
Helicobacter pylori - drug effects
Humans
Lansoprazole
Medical sciences
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Metronidazole - therapeutic use
Microbial Sensitivity Tests
Omeprazole - analogs & derivatives
Omeprazole - therapeutic use
Peptic Ulcer - microbiology
Pharmacology. Drug treatments
Proton Pump Inhibitors
Tinidazole - therapeutic use
Treatment Outcome
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Summary:Summary Aims : To evaluate the role of antibiotic susceptibility for the treatment outcome of proton pump inhibitor‐dependent and independent Helicobacter pylori eradication regimens. Methods : In a placebo‐controlled clinical study of peptic ulcer patients with H. pylori infection, patients were randomized to receive lansoprazole, clarithromycin and tinidazole twice‐daily, clarithromycin and tinidazole once‐daily with lansoprazole or with placebo. Helicobacter pylori status was assessed by culture and antibiotic susceptibility by E‐test minimal inhibitory concentration (MIC) in 205 clinical isolates. Results : Primary resistance to clarithromycin and metronidazole was 1 and 76%, respectively. In metronidazole susceptible strains eradication rates were similar at > 90% for all treatment groups (P = 0.49). With low‐level metronidazole resistance (4 μg/mL 
ISSN:0269-2813
1365-2036
1365-2036
DOI:10.1111/j.1365-2036.2004.01959.x