Angiotensin-related genes in patients with panic disorder

Enhanced respiratory variability and decreased heart rate variability have repeatedly been observed in patients with panic disorder. Prompted by the notion that angiotensin may be involved in the control of respiration, heart rate variability, and anxiety‐like behavior, we investigated the putative...

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Bibliographic Details
Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2004-05, Vol.127B (1), p.81-84
Main Authors: Olsson, Marie, Annerbrink, Kristina, Westberg, Lars, Melke, Jonas, Baghaei, Fariba, Rosmond, Roland, Holm, Göran, Andersch, Sven, Allgulander, Christer, Eriksson, Elias
Format: Article
Language:English
Subjects:
Alleles
Angiotensin
angiotensin converting enzyme
Angiotensinogen
Angiotensinogen - genetics
anxiety
chemistry
DNA
DNA - chemistry
DNA - genetics
DNA Mutational Analysis
Female
Fysiologi
Gene Frequency
Genetic
genetics
Genotype
Humans
Male
Medicin och hälsovetenskap
Middle Aged
Missense
Mutation
Mutation, Missense
Panic Disorder
Panic Disorder - genetics
Panic Disorder - pathology
pathology
Peptidyl-Dipeptidase A
Peptidyl-Dipeptidase A - genetics
Physiology
Polymorphism
Polymorphism, Genetic
Receptor
Receptor, Angiotensin, Type 1 - genetics
respiration
Type 1
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Summary:Enhanced respiratory variability and decreased heart rate variability have repeatedly been observed in patients with panic disorder. Prompted by the notion that angiotensin may be involved in the control of respiration, heart rate variability, and anxiety‐like behavior, we investigated the putative association between polymorphisms in three angiotensin‐related genes and panic disorder—angiotensinogen (AGT), angiotensin converting enzyme (ACE), and angiotensin II (ANG II) receptor type 1 (ATr1) in 72 patients with panic disorder and 504 controls. Allele and genotype distribution of the ATr1 A1166C allele and the AGT M235T did not differ between patients and controls. With respect to the ACE I/D polymorphism, the I allele was found to be more frequent in male (χ2 = 8.042, df = 1, P = 0.005), but not female, panic disorder patients than in controls. The results of this investigation provide preliminary evidence for the suggestion that angiotensin‐related genes may be associated with panic disorder in men. © 2004 Wiley‐Liss, Inc.
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.20164