Transcription factor AP-2 beta genotype, striatal dopamine D2 receptor density and cerebrospinal fluid monoamine metabolite concentrations in humans

Transcription factor AP-2 beta has been suggested to influence brain monoaminergic systems by regulating target genes. In order to explore a possible functional role, AP-2 beta genotype was analysed in relation to striatal dopamine D2 receptor density determined in vivo by positron emission tomograp...

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Published in:JOURNAL OF NEURAL TRANSMISSION 2004-04, Vol.111 (4), p.537-545
Main Authors: Damberg, M, Berggaard, C, Farde, L, Sedvall, G C, Joensson, E G
Format: Article
Language:English
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Summary:Transcription factor AP-2 beta has been suggested to influence brain monoaminergic systems by regulating target genes. In order to explore a possible functional role, AP-2 beta genotype was analysed in relation to striatal dopamine D2 receptor density determined in vivo by positron emission tomography in human subjects (n = 52). The AP-2 beta genotype was also analysed in relation to cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA), 3-methoxy-4-hydroxy-phenylglycol (MHPG) and 5-hydroxyindoleacetic acid (5-HIAA) in healthy human subjects (n = 90). There was no association between the AP-2 beta genotype and measures of dopamine receptor density, or CSF 5-HIAA concentrations. However, AP-2 beta genotype was associated with CSF-levels of HVA (in women) and MHPG. These data may suggest a functional involvement of AP-2 beta in the dopaminergic system, but should be interpreted with caution until replicated.
ISSN:0300-9564
DOI:10.1007/s00702-003-0097-4