Corticosteroid treatment of experimental arthritis retards cartilage destruction as determined by histology and serum COMP

Objective. To examine if changes in serum cartilage oligomeric matrix protein (COMP) correlate with the development of cartilage damage, as measured by histological grading, in corticosteroid-treated animals with collagen-induced arthritis (CIA). Methods. DA rats with established CIA were treated wi...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2004-04, Vol.43 (4), p.428-434
Main Authors: Larsson, E., Erlandsson Harris, H., Larsson, A., Månsson, B., Saxne, T., Klareskog, L.
Format: Article
Language:English
Subjects:
Animals
Antirheumatic Agents - therapeutic use
Arthritis, Experimental - blood
Arthritis, Experimental - drug therapy
Arthritis, Experimental - pathology
Betamethasone - analogs & derivatives
Betamethasone - therapeutic use
Biological and medical sciences
Biomarkers - blood
Cartilage oligomeric matrix protein (COMP)
Cartilage, Articular - pathology
Clinical Medicine
Collagen-induced arthritis
Corticosteroids
Diseases of the osteoarticular system
Dose-Response Relationship, Drug
Drug Monitoring - methods
Extracellular Matrix Proteins - blood
Female
Fibrinogen
Fibrinogen - metabolism
Glucocorticoids - therapeutic use
Glycoproteins - blood
Inflammatory joint diseases
Klinisk medicin
Matrilin Proteins
Medical and Health Sciences
Medical sciences
Medicin och hälsovetenskap
Rats
Reumatologi och inflammation
Rheumatology and Autoimmunity
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Summary:Objective. To examine if changes in serum cartilage oligomeric matrix protein (COMP) correlate with the development of cartilage damage, as measured by histological grading, in corticosteroid-treated animals with collagen-induced arthritis (CIA). Methods. DA rats with established CIA were treated with corticosteroids (betamethasone, 0.1 mg/kg body weight) or placebo (saline) intraperitoneally once daily after reaching an arthritis score exceeding 1. The treatment continued throughout the study. Arthritis progression was monitored by clinical scoring of paws, serial measurements of serum COMP and fibrinogen, and histological grading of paws. Results. Corticosteroid treatment reduced clinical signs of arthritis compared with placebo (arthritis score reduced, P 
ISSN:1462-0324
1462-0332
1462-0332
DOI:10.1093/rheumatology/keh073