Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis

Genome-wide screens for linkage in multiplex families with multiple sclerosis (MS) from United Kingdom, Sardinia, Italy and the Nordic countries (Denmark, Finland, Norway and Sweden) have each shown suggestive or potential linkage on chromosome 10. The partially overlapping regions identified by the...

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Bibliographic Details
Published in:Journal of neuroimmunology 2003-10, Vol.143 (1), p.31-38
Main Authors: Åkesson, Eva, Coraddu, Francesca, Marrosu, Maria Giovanna, Massacesi, Luca, Hensiek, Anke, Harbo, Hanne Flinstad, Oturai, Annette, Trojano, Maria, Momigliano-Richiardi, Patricia, Cocco, Eleonora, Murru, Raffaele, Hillert, Jan, Compston, Alastair, Sawcer, Stephen
Format: Article
Language:English
Subjects:
Alleles
Chromosomes, Human, Pair 10 - genetics
Finland - epidemiology
Genetic Linkage
Genetic Testing - methods
Genotype
Humans
International Cooperation
Italy - epidemiology
Linkage
Map density
Medicin och hälsovetenskap
Microsatellite Repeats - genetics
Multiple sclerosis
Multiple Sclerosis - epidemiology
Multiple Sclerosis - genetics
Scandinavian and Nordic Countries - epidemiology
Siblings
Software
Susceptibility gene
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Description
Summary:Genome-wide screens for linkage in multiplex families with multiple sclerosis (MS) from United Kingdom, Sardinia, Italy and the Nordic countries (Denmark, Finland, Norway and Sweden) have each shown suggestive or potential linkage on chromosome 10. The partially overlapping regions identified by these studies encompass around 60 cM of the chromosome. In order to explore this region further, we typed 13 microsatellite markers in the same 449 families originally studied in the individual screens. This additional genotyping increased the information extraction in the region from 52% to 79% and revealed increased support for linkage (MLS 2.5) peaking at 10p15.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2003.08.008