Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride: case reports

The combination of atovaquone and proguanil hydrochloride (Malarone, GlaxoSmithKline, NC) has shown high efficacy against Plasmodium falciparum with only mild side effects and has been registered for use in several countries, including Denmark, Germany, Sweden, the United Kingdom, and the United Sta...

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Bibliographic Details
Published in:BMJ 2003-03, Vol.326 (7390), p.628-629
Main Authors: Färnert, Anna, Lindberg, Johan, Gil, Pedro, Swedberg, Göte, Berqvist, Yngve, Thapar, Mita M, Lindegårdh, Niklas, Berezcky, Sándor, Björkman, A
Format: Article
Language:English
Subjects:
Antimalarials - therapeutic use
Antiprotozoal Agents - therapeutic use
Atovaquone
Bioavailability
Child, Preschool
Chromatography, High Pressure Liquid - methods
College students
Cytochrome
Cytochromes
Doctoral students
Drug Resistance
Drug Therapy, Combination
Failure
Falciparum malaria
Female
Gametocytes
Genetic mutation
Humans
Hydrochlorides
Infant
Malaria
Malaria, Falciparum - drug therapy
Male
Medical treatment failures
Mutation
Naphthoquinones - therapeutic use
Parasites
Patients
Polymerase chain reaction
Proguanil - therapeutic use
Tablets
Citations: Items that cite this one
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Summary:The combination of atovaquone and proguanil hydrochloride (Malarone, GlaxoSmithKline, NC) has shown high efficacy against Plasmodium falciparum with only mild side effects and has been registered for use in several countries, including Denmark, Germany, Sweden, the United Kingdom, and the United States. 1 Treatment failures have been attributed to suboptimal dosage, reinfections, or to a point mutation in the cytochrome b gene. 1 2 Bioavailability of atovaquone depends on the concomitant intake of a fatty diet, yet drug concentrations were not analysed in these reports.
ISSN:0959-8138
1756-1833
1468-5833
1756-1833
DOI:10.1136/bmj.326.7390.628