Impairment of peripheral sensory innervation in senescence

Sensorimotor disturbances are common among elderly and one of the main factors depreciating life quality in senescence. Mechanistically sensory deficits during aging include not only degenerative and regressive events but also phenotypic switches among sensory neurons as well as remodeling of sensor...

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Bibliographic Details
Published in:Autonomic Neuroscience: Basic and Clinical 2002-02, Vol.96 (1), p.43-49
Main Authors: Ulfhake, B, Bergman, E, Fundin, B.T
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Aging - pathology
Animals
Biological and medical sciences
Cell Communication - physiology
Ganglia, Spinal - pathology
Ganglia, Spinal - physiopathology
Humans
Mechanoreceptors - pathology
Mechanoreceptors - physiopathology
Mechanosensation
Medicin och hälsovetenskap
Nerve Degeneration - pathology
Nerve Degeneration - physiopathology
Nerve Growth Factors - metabolism
Neurons, Afferent - metabolism
Neurons, Afferent - pathology
Neurotrophic factors
Peripheral Nerves - pathology
Peripheral Nerves - physiopathology
Sensation Disorders - etiology
Sensation Disorders - pathology
Sensation Disorders - physiopathology
Skin - innervation
Skin - physiopathology
Target dependence
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Summary:Sensorimotor disturbances are common among elderly and one of the main factors depreciating life quality in senescence. Mechanistically sensory deficits during aging include not only degenerative and regressive events but also phenotypic switches among sensory neurons as well as remodeling of sensory innervation. The pattern of changes suggests that an underlying mechanism is a sustained dependence of sensory neurons on target tissues, and that this dependence, at least in part, appears to be mediated through signaling by target-derived trophic factors. This review presents and discusses evidence supporting this notion.
ISSN:1566-0702
1872-7484
DOI:10.1016/S1566-0702(01)00368-X