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Impairment of peripheral sensory innervation in senescence
Sensorimotor disturbances are common among elderly and one of the main factors depreciating life quality in senescence. Mechanistically sensory deficits during aging include not only degenerative and regressive events but also phenotypic switches among sensory neurons as well as remodeling of sensor...
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| Published in: | Autonomic Neuroscience: Basic and Clinical 2002-02, Vol.96 (1), p.43-49 |
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| Main Authors: | , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c529t-a819bd060128de6abe038c1c86c0e478ca5882ed95725d78d7e11a1612ce9d183 |
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| cites | cdi_FETCH-LOGICAL-c529t-a819bd060128de6abe038c1c86c0e478ca5882ed95725d78d7e11a1612ce9d183 |
| container_end_page | 49 |
| container_issue | 1 |
| container_start_page | 43 |
| container_title | Autonomic Neuroscience: Basic and Clinical |
| container_volume | 96 |
| creator | Ulfhake, B Bergman, E Fundin, B.T |
| description | Sensorimotor disturbances are common among elderly and one of the main factors depreciating life quality in senescence. Mechanistically sensory deficits during aging include not only degenerative and regressive events but also phenotypic switches among sensory neurons as well as remodeling of sensory innervation. The pattern of changes suggests that an underlying mechanism is a sustained dependence of sensory neurons on target tissues, and that this dependence, at least in part, appears to be mediated through signaling by target-derived trophic factors. This review presents and discusses evidence supporting this notion. |
| doi_str_mv | 10.1016/S1566-0702(01)00368-X |
| format | article |
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| ispartof | Autonomic Neuroscience: Basic and Clinical, 2002-02, Vol.96 (1), p.43-49 |
| issn | 1566-0702 1872-7484 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Aging Aging - metabolism Aging - pathology Animals Biological and medical sciences Cell Communication - physiology Ganglia, Spinal - pathology Ganglia, Spinal - physiopathology Humans Mechanoreceptors - pathology Mechanoreceptors - physiopathology Mechanosensation Medicin och hälsovetenskap Nerve Degeneration - pathology Nerve Degeneration - physiopathology Nerve Growth Factors - metabolism Neurons, Afferent - metabolism Neurons, Afferent - pathology Neurotrophic factors Peripheral Nerves - pathology Peripheral Nerves - physiopathology Sensation Disorders - etiology Sensation Disorders - pathology Sensation Disorders - physiopathology Skin - innervation Skin - physiopathology Target dependence |
| title | Impairment of peripheral sensory innervation in senescence |
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