Reduced developmental potential in oocytes from Women with endometriosis

To study retrospectively the outcome of intracytoplasmatic sperm injection (ICSI) in women with endometriosis compared with women with no known female infertility factor. All couples treated with ICSI because of male infertility plus verified endometriosis (n = 26) and all couples treated with ICSI...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2001-12, Vol.18 (12), p.644-649
Main Authors: NORENSTEDT, Sophie Naffah, LINDEROTH-NAGY, Christina, BERGENDAL, Annica, SJÖBLOM, Peter, BERGQVIST, Agneta
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Endometriosis - physiopathology
Endometriosis - therapy
Female
Female genital diseases
Fertilization in Vitro
Gynecology. Andrology. Obstetrics
Humans
Infertility, Female - therapy
Male
Medical sciences
Medicin och hälsovetenskap
Non tumoral diseases
Oligospermia - therapy
Oocytes - physiology
Pregnancy
Pregnancy Outcome
Sperm Injections, Intracytoplasmic
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Summary:To study retrospectively the outcome of intracytoplasmatic sperm injection (ICSI) in women with endometriosis compared with women with no known female infertility factor. All couples treated with ICSI because of male infertility plus verified endometriosis (n = 26) and all couples treated with ICSI because of male infertility only (n = 125) during the period January 1995 to June 1999 were included. Data were collected from patient files and ICSI protocols. The time to complete down regulation was significantly longer (p = 0.0108), the dose of FSH significantly higher (0.0247), the day for oocyte pickup significantly later (p = 0.0091), and the cleavage rate of oocytes significantly lower (p = 0.0011) in women with endometriosis compared with controls. There was no significant difference in implantation rate or pregnancy rate between the groups. Women with endometriosis presented significantly reduced follicular response and oocyte cleavage rate, two mechanisms that might be related to a disturbed oogenesis.
ISSN:1058-0468
1573-7330
DOI:10.1023/A:1013111200251