A Clinically Prognostic Scoring System for Patients Receiving Highly Active Antiretroviral Therapy: Results from the EuroSIDA Study

The risk of clinical progression for human immunodeficiency virus (HIV)–infected persons receiving treatment with highly active antiretroviral therapy (HAART) is poorly defined. From an inception cohort of 8457 HIV-infected persons, 2027 patients who started HAART during prospective follow-up were e...

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Bibliographic Details
Published in:The Journal of infectious diseases 2002-01, Vol.185 (2), p.178-187
Main Authors: Lundgren, Jens D., Mocroft, Amanda, Gatell, Jose M., Ledergerber, Bruno, Monforte, Antonella D’Arminio, Hermans, Philippe, Goebel, Frank-Detlef, Blaxhult, Anders, Kirk, Ole, Phillips, Andrew N.
Format: Article
Language:English
Subjects:
Adult
AIDS
Anemia
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral Therapy, Highly Active
Antiretrovirals
Biological and medical sciences
CD4 Lymphocyte Count
Cohort Studies
Disease risk
Female
Hemoglobins
Highly active antiretroviral therapy
HIV
HIV 1
HIV Infections - drug therapy
HIV Infections - immunology
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Major Articles
Male
Medical sciences
Medicin och hälsovetenskap
Pharmacology. Drug treatments
Prognosis
Prospective Studies
RNA
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viruses
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Summary:The risk of clinical progression for human immunodeficiency virus (HIV)–infected persons receiving treatment with highly active antiretroviral therapy (HAART) is poorly defined. From an inception cohort of 8457 HIV-infected persons, 2027 patients who started HAART during prospective follow-up were examined. Results were validated in another 2 groups of patients (n=1946 and n=1442). In total, 200 patients (9.9%) experienced clinical progression during 5177 person-years (incidence, 3.9/100 years). The most recently measured CD4 cell count, virus load, and hemoglobin level all were independently related to the risk of clinical progression, as was a diagnosis of severe AIDS before the start of HAART. On the basis of these findings, a scoring system was derived (range, 0–17). A single unit increase in the score was associated with a 38% increased risk of clinical progression (relative hazard, 1.38; 95% confidence interval, 1.33–1.43; P
ISSN:0022-1899
1537-6613
DOI:10.1086/338267