Ethnic variation in genotype frequencies of a p53 intron 7 polymorphism

Using a PCR–restriction enzyme-based method we found large ethnic variations when a C→T polymorphism in the human p53 gene at position 14181 in intron 7 was studied in Finnish, Polish, Hungarian, Italian, Japanese, Indian and Chinese populations. The largest variations were found between Caucasian a...

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Bibliographic Details
Published in:Mutagenesis 2001-11, Vol.16 (6), p.475-478
Main Authors: Berggren, Petra, Kumar, Rajiv, Steineck, Gunnar, Ichiba, Masayoshi, Hemminki, Kari
Format: Article
Language:English
Subjects:
Asian Continental Ancestry Group - genetics
Biological and medical sciences
China - epidemiology
DNA - genetics
DNA, Neoplasm - genetics
Ethnic Groups - genetics
Ethnic Groups - statistics & numerical data
European Continental Ancestry Group - genetics
Finland - epidemiology
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genes, p53 - genetics
Genetic Variation - genetics
Genotype
Humans
Hungary - epidemiology
India - epidemiology
Introns - genetics
Italy - epidemiology
Japan - epidemiology
Medicin och hälsovetenskap
Molecular and cellular biology
p53 gene
Poland - epidemiology
Polymorphism, Genetic - genetics
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Summary:Using a PCR–restriction enzyme-based method we found large ethnic variations when a C→T polymorphism in the human p53 gene at position 14181 in intron 7 was studied in Finnish, Polish, Hungarian, Italian, Japanese, Indian and Chinese populations. The largest variations were found between Caucasian and Asian, genotype frequencies varied from C 0.95 and T 0.05 in the Finnish population to C 0.67 and T 0.33 in the Chinese population, the relative risk (RR) for T being 6.5 (95% CI 3.4–12.3, P < 0.001). Variations were also found between Finnish and Italian and between Italian and Chinese (RR for T 2.4, 95% CI 1.2–4.9 and 2.7, 95% CI 1.7–4.2, respectively).
ISSN:0267-8357
1464-3804
1464-3804
DOI:10.1093/mutage/16.6.475