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Genetic susceptibility to MS : a second stage analysis in Canadian MS families

Four published genome screens have identified a number of markers with increased sharing in multiple sclerosis (MS) families, although none has reached statistical significance. One hundred and five markers previously identified as showing increased sharing in Canadian, British, Finnish, and America...

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Published in:Neurogenetics 2001-07, Vol.3 (3), p.145-151
Main Authors: DYMENT, David A, WILLER, Cristen J, KASTRUKOFF, Lorne, OGER, Joel, METZ, Luanne, WARREN, Sharon, HADER, Walter, POWER, Cristopher, AUTY, Anthony, NATH, Avindra, NELSON, Robert, FREEDMAN, Mark, SCOTT, Beverly, BRUNET, Donald, PAULSETH, John E, RICE, George, O'CONNOR, Paul, DUQUETTE, Pierre, LAPIERRE, Yves, FRANCIS, Gordon, BOUCHARD, Jean-Pierre, MURRAY, T. John, BHAN, Virender, ARMSTRONG, Holly, MAXNER, Charles, PRYSE-PHILLIPS, William, STEFANELLI, Mark, SADOVNICK, A. Dessa, RISCH, Neil, EBERS, George C, LIGERS, Arturs, HILLERT, Jan, PATY, Donald W, HASHIMOTO, Stanley, DEVONSHIRE, Virginia, HOOGE, John
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Language:English
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Summary:Four published genome screens have identified a number of markers with increased sharing in multiple sclerosis (MS) families, although none has reached statistical significance. One hundred and five markers previously identified as showing increased sharing in Canadian, British, Finnish, and American genome screens were genotyped in 219 sibling pairs ascertained from the database of the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS). No markers examined met criteria for significant linkage. Markers located at 5p14 and 17q22 were analyzed in a total of 333 sibling pairs and attained mlod scores of 2.27 and 1.14, respectively. The known HLA Class II DRB1 association with MS was confirmed (P
ISSN:1364-6745
1364-6753
DOI:10.1007/s100480100113