Mitogen-activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction

Exercise has numerous growth and metabolic effects in skeletal muscle, including changes in glycogen metabolism, glucose and amino acid uptake, protein synthesis and gene transcription. However, the mechanism(s) by which exercise regulates intracellular signal transduction to the transcriptional mac...

Full description

Saved in:
Bibliographic Details
Published in:Acta physiologica Scandinavica 2001-07, Vol.172 (3), p.227-238
Main Authors: Widegren, U., Ryder, J. W., Zierath, J. R.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
exercise
Exercise - physiology
extracellular signal-regulated kinase
Fundamental and applied biological sciences. Psychology
gene expression
Humans
Medicin och hälsovetenskap
mitogen-activated protein kinase
Mitogen-Activated Protein Kinases - metabolism
muscle contraction
Muscle Contraction - physiology
Muscle, Skeletal - physiology
Physical Exertion - physiology
Signal Transduction - physiology
stress-activated protein kinase
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Exercise has numerous growth and metabolic effects in skeletal muscle, including changes in glycogen metabolism, glucose and amino acid uptake, protein synthesis and gene transcription. However, the mechanism(s) by which exercise regulates intracellular signal transduction to the transcriptional machinery in the nucleus, thus modulating gene expression, is largely unknown. This review will provide insight on potential intracellular signalling mechanisms by which muscle contraction/exercise leads to changes in gene expression. Mitogen‐activated protein kinase (MAPK) cascades are associated with increased transcriptional activity. The MAPK family members can be separated into distinct parallel pathways including the extracellular signal‐regulated kinase (ERK) 1/2, the stress‐activated protein kinase cascades (SAPK1/JNK and SAPK2/p38) and the extracellular signal‐regulated kinase 5 (ERK5). Acute exercise elicits signal transduction via MAPK cascades in direct response to muscle contraction. Thus, MAPK pathways appear to be potential physiological mechanisms involved in the exercise‐induced regulation of gene expression in skeletal muscle.
ISSN:0001-6772
1365-201X
DOI:10.1046/j.1365-201x.2001.00855.x