Innate immunity and autoimmunity: from self-protection to self-destruction

Innate immune responses provide the body with its first line of defense against infections. Signals generated by a subset of lymphocytes, including natural killer (NK) cells and natural killer T (NKT) cells, during the early host response might have an additional role in determining the nature of do...

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Bibliographic Details
Published in:Trends in Immunology 2001-02, Vol.22 (2), p.97-101
Main Authors: Shi, Fu-Dong, Ljunggren, Hans-Gustaf, Sarvetnick, Nora
Format: Article
Language:English
Subjects:
Animals
Autoimmune Diseases - immunology
Autoimmunity
Humans
Immunity, Active
Immunity, Innate
Innate immunity
Killer Cells, Natural - immunology
Natural killer cells
Natural killer T cells
T-Lymphocyte Subsets - immunology
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Summary:Innate immune responses provide the body with its first line of defense against infections. Signals generated by a subset of lymphocytes, including natural killer (NK) cells and natural killer T (NKT) cells, during the early host response might have an additional role in determining the nature of downstream adaptive immune responses. Here, Fu-Dong Shi, Hans-Gustaf Ljunggren and Nora Sarvetnick discuss the role of cellular and soluble components of innate immunity in the development of autoimmune diseases. Some putative pathways leading from innate immunity to autoimmunity are proposed.
ISSN:1471-4906
1471-4981
DOI:10.1016/S1471-4906(00)01821-4