Influence of exercise intensity on ERK/MAP kinase signalling in human skeletal muscle

The mitogen-activated protein (MAP) kinase pathways have been highlighted as a possible link between exercise and adaptive changes in skeletal muscle. In this study, the effect of exercise intensity on the activation of the ERK/MAP kinase pathway was investigated in human skeletal muscle. One-leg ex...

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Bibliographic Details
Published in:Pflügers Archiv 2000-12, Vol.441 (2-3), p.317-322
Main Authors: Widegren, U, Wretman, C, Lionikas, A, Hedin, G, Henriksson, J
Format: Article
Language:English
Subjects:
Adult
Cyclic AMP Response Element-Binding Protein - metabolism
Exercise - physiology
Female
Freeze Drying
Humans
Kinases
Male
Mitogen-Activated Protein Kinase 1 - metabolism
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases - metabolism
Muscle, Skeletal - enzymology
Muscular system
Oxygen Consumption
Phosphorylation
Proteins
Signal Transduction
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Summary:The mitogen-activated protein (MAP) kinase pathways have been highlighted as a possible link between exercise and adaptive changes in skeletal muscle. In this study, the effect of exercise intensity on the activation of the ERK/MAP kinase pathway was investigated in human skeletal muscle. One-leg exercise at low (40% maximal oxygen consumption, VO2max for 30 min) and high (75% VO2max for 30 min) intensity resulted in 11.5+8. I-fold and 39.7+/-6.3-fold (mean +/-SEM) increases in ERK1/2 phosphorylation (P
ISSN:0031-6768
1432-2013
DOI:10.1007/s004240000417