Methadone, ciprofloxacin, and adverse drug reactions

Ciprofloxacin, given to a patient successfully treated with methadone for more than 6 years, caused profound sedation, confusion, and respiratory depression. We suggest that this was caused by ciprofloxacin inhibition of CYP1A2 and CYP3A4 activity, two of the cytochrome p450 isozymes involved in the...

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Bibliographic Details
Published in:The Lancet (British edition) 2000-12, Vol.356 (9247), p.2069-2070
Main Authors: Herrlin, Karin, Segerdahl, Märta, Gustafsson, Lars L, Kalso, Eija
Format: Article
Language:English
Subjects:
Adult
Analgesics, Opioid - pharmacokinetics
Anti-Infective Agents - adverse effects
Antibiotics
Biological and medical sciences
Ciprofloxacin - adverse effects
Confusion - chemically induced
Cytochrome
Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 CYP2D6 Inhibitors
Drug abuse
Drug Interactions
Drug therapy
Drug toxicity and drugs side effects treatment
Enzymes
Female
Humans
Medical sciences
Medicin och hälsovetenskap
Metabolism
Metabolites
Methadone
Methadone - pharmacokinetics
Pharmacology. Drug treatments
Respiratory Insufficiency - chemically induced
Side effects
Smoking - physiopathology
Toxicity: nervous system and muscle
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Summary:Ciprofloxacin, given to a patient successfully treated with methadone for more than 6 years, caused profound sedation, confusion, and respiratory depression. We suggest that this was caused by ciprofloxacin inhibition of CYP1A2 and CYP3A4 activity, two of the cytochrome p450 isozymes involved in the metabolism of methadone.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(00)03409-7