Infections as a major preventable cause of human cancer

. Kuper H, Adami H‐O & Trichopoulos D (Harvard School of Public Health, Boston, MA, USA; Karolinska Institute, Stockholm, Sweden; University of Athens Medical School, Greece). Infections as a major preventable cause of human cancer (Internal Medicine in the 21st Century). J Intern Med 2000; 248:...

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Bibliographic Details
Published in:Journal of internal medicine 2000-09, Vol.248 (3), p.171-183
Main Authors: Kuper, H., Adami, H.‐O., Trichopoulos, D.
Format: Article
Language:English
Subjects:
aetiology
Animals
Biological and medical sciences
cancer
Clonorchiasis - complications
Helicobacter Infections - complications
Helicobacter pylori
Human viral diseases
Humans
infections
Infectious diseases
Medical sciences
Medicin och hälsovetenskap
Neoplasms - etiology
Neoplasms - prevention & control
Primary Prevention
public health
Schistosomiasis - complications
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virus Diseases - complications
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Summary:. Kuper H, Adami H‐O & Trichopoulos D (Harvard School of Public Health, Boston, MA, USA; Karolinska Institute, Stockholm, Sweden; University of Athens Medical School, Greece). Infections as a major preventable cause of human cancer (Internal Medicine in the 21st Century). J Intern Med 2000; 248: 171–183. Infections may be responsible for over 15% of all malignancies worldwide. Important mechanisms by which infectious agents may induce carcinogenesis include the production of chronic inflammation, the transformation of cells by insertion of oncogenes and inhibition of tumour suppressors, and the induction of immunosuppression. Common characteristics shared by infectious agents linked to malignancies are that they are persistent in the host, often highly prevalent in the host population and induce cancer after a long latency. The associations between a selection of infectious agents and malignancies are covered in detail.
ISSN:0954-6820
1365-2796
DOI:10.1046/j.1365-2796.2000.00742.x