In vivo Cataract after Repeated Exposure to Ultraviolet Radiation

The purpose of this study was to investigate the effects of repeated close-to-threshold ultraviolet radiation (UVR) doses in the rat lens. Sprague Dawley rats received two UVR exposures (λmax=300 nm, λ0.5=10 nm) separated by different time intervals. The animals were unilaterally irradiated with 4 k...

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Bibliographic Details
Published in:Experimental eye research 2000-04, Vol.70 (4), p.451-456
Main Authors: AYALA, MARCELO N., MICHAEL, RALPH, SÖDERBERG, PER G.
Format: Article
Language:English
Subjects:
additivity
Animals
Biological and medical sciences
cataract
Cataract - etiology
Cataract - physiopathology
Female
in vivo
lens
Lens diseases
light scattering
Medical sciences
Medicin och hälsovetenskap
Ophthalmology
Photomicrography
Rats
Rats, Sprague-Dawley
Scattering, Radiation
Statistics, Nonparametric
Threshold Limit Values
Time Factors
time intervals
ultraviolet radiation
Ultraviolet Rays - adverse effects
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Summary:The purpose of this study was to investigate the effects of repeated close-to-threshold ultraviolet radiation (UVR) doses in the rat lens. Sprague Dawley rats received two UVR exposures (λmax=300 nm, λ0.5=10 nm) separated by different time intervals. The animals were unilaterally irradiated with 4 kJ  m2-1UVR in each exposure. The intervals between both exposures were: 6 hr, 1 day, 3 days, 9 days and 30 days. At 1 week after the last exposure both lenses were removed, microphotographs were taken and intensity of forward light scattering was measured. Evaluating the difference between exposed and non-exposed eyes, the forward light scattering in the 6 hr and 1 day interval group was not significantly different. The most intense forward light scattering was found in the group that was allowed 3 days interval between exposures. Thereafter, the intensity of scattering decreased as the time interval between exposures increased. The lowest intensity of forward light scattering was detected in the 30 days interval group. Three days after a UVR exposure, the lens showed the highest sensitivity for a second UVR exposure. One month after the first exposure lenses undergo physiological repair and interactions between exposures seem to decrease.
ISSN:0014-4835
1096-0007
DOI:10.1006/exer.1999.0801