In vitro chemosensitivity testing in acute non lymphocytic leukemia using the bioluminescence ATP assay

The ATP assay is a short term in vitro chemosensitivity assay where the amount of viable cells are determined by their content of ATP. The aim of the study was to compare the in vitro results of six cytostatic drugs to the clinical outcome in 83 acute non-lymphocytic leukemia (ANLL) patients. The se...

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Bibliographic Details
Published in:Leukemia research 2000-05, Vol.24 (5), p.445-452
Main Authors: Möllgård, Lars, Tidefelt, Ulf, Sundman-Engberg, Britt, Löfgren, Christina, Paul, Christer
Format: Article
Language:English
Subjects:
Acute Disease
Adenosine Triphosphate - analysis
Antibiotics, Antineoplastic - pharmacology
Antibiotics, Antineoplastic - therapeutic use
Biological Assay
Bioluminiscence ATP assay
Cell Survival
Chemosensitivity
Cytotoxicity
Daunorubicin - pharmacology
Daunorubicin - therapeutic use
Drug resistance
Drug Resistance, Microbial
Drug Resistance, Neoplasm
Humans
Leukemia, Myeloid - drug therapy
Leukemia, Myeloid - metabolism
Leukemia, Myeloid - pathology
Luminescent Measurements
Myeloid leukemia
Sensitivity and Specificity
Tumor Cells, Cultured
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Summary:The ATP assay is a short term in vitro chemosensitivity assay where the amount of viable cells are determined by their content of ATP. The aim of the study was to compare the in vitro results of six cytostatic drugs to the clinical outcome in 83 acute non-lymphocytic leukemia (ANLL) patients. The secondary ANLL at diagnosis showed an in vitro resistance to daunorubicin that was significantly higher compared to de novo ANLL at diagnosis ( P
ISSN:0145-2126
1873-5835
DOI:10.1016/S0145-2126(00)00003-5