A case of allergy to cow's milk hydrolysate

We here report a girl, now 3 years old, who has suffered from severe food allergy since her first year of life. She was strongly allergic to cow's milk, and had high levels of IgE antibody (AB) to casein (210 kU/l), β‐lactoglobulin (43 kU/l), and α‐lactalbumin (23 kU/l) at 12 months of age. In...

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Bibliographic Details
Published in:Allergy (Copenhagen) 1999-12, Vol.54 (12), p.1322-1326
Main Authors: Nilsson, C., Lilja, G., Öman, H., Halldén, G., Härfast, B., Lundberg, M.
Format: Article
Language:English
Subjects:
Allergic diseases
Animals
atopy
Biological and medical sciences
Biomarkers
Cattle
Child, Preschool
children
cow's milk allergy
cow's milk hydrolysate
Cytokines - metabolism
Eosinophils - immunology
Female
food allergy
Humans
Hydrolysis
Immunopathology
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Medical sciences
Medicin och hälsovetenskap
Milk Hypersensitivity - diagnosis
Milk Proteins - adverse effects
Milk Proteins - immunology
Other localizations
Radioallergosorbent Test
Skin Tests
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Summary:We here report a girl, now 3 years old, who has suffered from severe food allergy since her first year of life. She was strongly allergic to cow's milk, and had high levels of IgE antibody (AB) to casein (210 kU/l), β‐lactoglobulin (43 kU/l), and α‐lactalbumin (23 kU/l) at 12 months of age. In addition, at the same age, she showed positive (2–4+) skin prick reactions to both unboiled and boiled formulas (Profylac, Nutramigen, and Neocate), besides being positive in RAST to Nutramigen (0.6 kU/l). During the first 3 years, IgE Ab levels against casein and Nutramigen increased to 310 and 1.6 kU/l, respectively. Furthermore, at 3 years of age, she had positive RAST to 14 of 15 tested food allergens, being negative only to codfish. Assessment of eosinophil‐related markers revealed high total eosinophil count, increased eosinophil activity, and a low ratio of interferon (IFN)‐γ:IL‐5, indicating enhanced IL‐5 production. The food allergy was correlated to poor weight gain and increasing problems with atopic allergy in the airways.
ISSN:0105-4538
1398-9995
DOI:10.1034/j.1398-9995.1999.00236.x