Association between a promoter polymorphism in the dopamine D2 receptor gene and schizophrenia

Genetic factors and dopamine receptor dysfunction have been implicated in the pathophysiology of schizophrenia. Recently, an association between a putative functional promoter polymorphism (−141C Ins/Del) in the dopamine D2 receptor gene and schizophrenia was reported. We investigated unrelated Swed...

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Bibliographic Details
Published in:Schizophrenia research 1999-11, Vol.40 (1), p.31-36
Main Authors: Jönsson, Erik G, Nöthen, Markus M, Neidt, Helge, Forslund, Kaj, Rylander, Gunnar, Mattila-Evenden, Marja, Åsberg, Marie, Propping, Peter, Sedvall, Göran C
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Alleles
Association
Biological and medical sciences
DNA Primers - genetics
Dopamine D2 receptor gene locus
Dopamine receptor
Female
Gene Expression - genetics
Genetics
Humans
Male
Medical sciences
Medicin och hälsovetenskap
Phenotype
Polymorphism, Genetic - genetics
Promoter Regions, Genetic - genetics
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Receptors, Dopamine D2 - genetics
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - genetics
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Summary:Genetic factors and dopamine receptor dysfunction have been implicated in the pathophysiology of schizophrenia. Recently, an association between a putative functional promoter polymorphism (−141C Ins/Del) in the dopamine D2 receptor gene and schizophrenia was reported. We investigated unrelated Swedish schizophrenic patients ( n=129) and control subjects ( n=179) for the same polymorphism. Similarly to a previous Japanese report, the −141C Del allele frequency was significantly lower in patients than controls (χ 2=4.4, 1 df, p
ISSN:0920-9964
1573-2509
DOI:10.1016/S0920-9964(99)00033-X