Angiotensin-converting enzyme gene polymorphism influences degree of left ventricular hypertrophy and its regression in patients undergoing operation for aortic stenosis

Insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been associated with increased left ventricular hypertrophy (LVH) in patients with cardiomyopathy and congestive heart failure. Patients with aortic stenosis (AS) have varying degrees of LVH at a given valve...

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Bibliographic Details
Published in:The American journal of cardiology 1999-10, Vol.84 (8), p.909-913
Main Authors: Dellgren, Göran, Eriksson, Maria J, Blange, Irina, Brodin, Lars-Åke, Rådegran, Kjell, Sylvén, Christer
Format: Article
Language:English
Subjects:
Aged
Analysis of Variance
Aortic Valve Stenosis - enzymology
Aortic Valve Stenosis - genetics
Aortic Valve Stenosis - surgery
Biological and medical sciences
Cardiac arrhythmia
Cardiology. Vascular system
Coronary vessels
Echocardiography, Doppler
Endocardial and cardiac valvular diseases
Enzymes
Female
Gene Deletion
Gene Frequency
Genes
Genotype
Heart
Heart Valve Prosthesis Implantation
Humans
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - enzymology
Hypertrophy, Left Ventricular - genetics
Linear Models
Male
Medical sciences
Medicin och hälsovetenskap
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic
Prospective Studies
Studies
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Summary:Insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been associated with increased left ventricular hypertrophy (LVH) in patients with cardiomyopathy and congestive heart failure. Patients with aortic stenosis (AS) have varying degrees of LVH at a given valve area. The aim of this study was to examine the relation between ACE gene polymorphism and the degree of LVH in patients undergoing operation for AS. Eighty-two patients who underwent operation for AS with a stentless valve were followed prospectively with echocardiographic assessments of left ventricular mass index (LVMI). ACE gene polymorphism was determined by polymerase chain reaction. The genotype (DD, ID, and II) frequency was the same as in healthy controls. The pressure difference across the aortic valve did not differ between genotypes. Patients with the DD genotype of the ACE gene had a higher LVMI (197 ± 47 g/m 2) preoperatively than those with ID (175 ± 41 g/m 2) or II (155 ± 43 g/m 2) genotypes (p = 0.01). LVMI decreased significantly in DD (p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00464-6