The molecular pathogenesis of Semliki Forest virus: a model virus made useful?

Semliki Forest virus (SFV) has for many years been used as a model to study the molecular biology of RNA virus multiplication, since it grows well and to high titre in cultured cells such as BHK cells and chick embryo cells. Initially, studies on the pathogenesis of SFV were descriptive, but recent...

Full description

Saved in:
Bibliographic Details
Published in:Journal of general virology 1999-09, Vol.80 ( Pt 9) (9), p.2287-2297
Main Authors: Atkins, Gregory J, Sheahan, Brian J, Liljeström, Peter
Format: Article
Language:English
Subjects:
Alphavirus Infections - etiology
Animals
Apoptosis
BHK cells
chick embryo cells
Defective Viruses - physiology
Demyelinating Diseases - etiology
Fetal Death - etiology
Genetic Vectors
Humans
Semliki Forest virus
Semliki forest virus - genetics
Semliki forest virus - immunology
Semliki forest virus - pathogenicity
Virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Semliki Forest virus (SFV) has for many years been used as a model to study the molecular biology of RNA virus multiplication, since it grows well and to high titre in cultured cells such as BHK cells and chick embryo cells. Initially, studies on the pathogenesis of SFV were descriptive, but recent advances have facilitated analysis of the pathogenesis of SFV at the molecular level. As with several other viruses, it has become apparent that some characteristics of SFV, which normally contribute to pathogenesis, may be manipulated to treat disease rather than cause it.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-80-9-2287