Loading…
Genetic link to cervical tumours
Cervical cancer is strongly associated with infection by oncogenic types of human papilloma virus (HPV). But only a small fraction of those infected develop cancer, indicating that other factors contribute to the progression to cervical cancer. We have compared incidence of the disease in relatives...
Saved in:
Published in: | Nature (London) 1999-07, Vol.400 (6739), p.29-30 |
---|---|
Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c533t-72e228453f5fe06f4ee6e7ec1da59842f436b0ffb305fb9b639bb8a34a8c89733 |
---|---|
cites | |
container_end_page | 30 |
container_issue | 6739 |
container_start_page | 29 |
container_title | Nature (London) |
container_volume | 400 |
creator | Magnusson, Patrik K. E Sparén, Pär Gyllensten, Ulf B |
description | Cervical cancer is strongly associated with infection by oncogenic types of human papilloma virus (HPV). But only a small fraction of those infected develop cancer, indicating that other factors contribute to the progression to cervical cancer. We have compared incidence of the disease in relatives of cases of cervical tumour and controls, and find a significant familial clustering among biological, but not adoptive, relatives. We find no difference in the risk to siblings who have a mother or father in common, so the clustering cannot be explained by vertical transmission of HPV from mother to child. These results provide epidemiological evidence of a genetic predisposition to cervical cancer. |
doi_str_mv | 10.1038/21801 |
format | article |
fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_604938</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1241031851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c533t-72e228453f5fe06f4ee6e7ec1da59842f436b0ffb305fb9b639bb8a34a8c89733</originalsourceid><addsrcrecordid>eNqFkk9P3DAQxa2qVdkCn6BSFVVqewod2-M_OVaoQCWkXujZcrLjKpBNtnZCxbfHSxYWIQEnW57fe2N7HmOHHI44SPtdcAv8DVtwNLpEbc1btgAQtgQr9R77kNIlAChu8D3b44AgBeKCFafU09g2Rdf2V8U4FA3F67bxXTFOq2GK6YC9C75LdLhd99mfk58Xx2fl-e_TX8c_zstGSTmWRpAQFpUMKhDogESaDDV86VVlUQSUuoYQagkq1FWtZVXX1kv0trGVkXKflbNv-k_rqXbr2K58vHGDb9326CrvyGnAStrM22f5dRyWO9G9kCsrQWidpd9maeb-TZRGt2pTQ13nexqm5CwYoStr8VXS5FcZ5Nxk8uuL5MZPiqp6FeS5tzKCZ_DzE_Ayz6PPM3ACEI1C3Lh9maEmDilFCg__wMFtcuHucpG5T1uzqV7R8hE1B2F3rZRL_V-Ku25PnT7OYO_HKdKD01y9BXFdxQ4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204475449</pqid></control><display><type>article</type><title>Genetic link to cervical tumours</title><source>Nature</source><creator>Magnusson, Patrik K. E ; Sparén, Pär ; Gyllensten, Ulf B</creator><creatorcontrib>Magnusson, Patrik K. E ; Sparén, Pär ; Gyllensten, Ulf B</creatorcontrib><description>Cervical cancer is strongly associated with infection by oncogenic types of human papilloma virus (HPV). But only a small fraction of those infected develop cancer, indicating that other factors contribute to the progression to cervical cancer. We have compared incidence of the disease in relatives of cases of cervical tumour and controls, and find a significant familial clustering among biological, but not adoptive, relatives. We find no difference in the risk to siblings who have a mother or father in common, so the clustering cannot be explained by vertical transmission of HPV from mother to child. These results provide epidemiological evidence of a genetic predisposition to cervical cancer.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/21801</identifier><identifier>PMID: 10403244</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Age of Onset ; Female ; Genetic Predisposition to Disease ; Human papillomavirus ; Humanities and Social Sciences ; Humans ; Infectious Disease Transmission, Vertical ; Medicin och hälsovetenskap ; multidisciplinary ; Papillomaviridae ; Papillomavirus Infections - transmission ; Registries ; Risk Assessment ; Science ; Science (multidisciplinary) ; scientific-correspondence ; Sweden - epidemiology ; Tumor Virus Infections - transmission ; Uterine Cervical Neoplasms - epidemiology ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - virology</subject><ispartof>Nature (London), 1999-07, Vol.400 (6739), p.29-30</ispartof><rights>Macmillan Magazines Ltd. 1999</rights><rights>Copyright Nature Publishing Group Jul 1, 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-72e228453f5fe06f4ee6e7ec1da59842f436b0ffb305fb9b639bb8a34a8c89733</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10403244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:15830266$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Magnusson, Patrik K. E</creatorcontrib><creatorcontrib>Sparén, Pär</creatorcontrib><creatorcontrib>Gyllensten, Ulf B</creatorcontrib><title>Genetic link to cervical tumours</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Cervical cancer is strongly associated with infection by oncogenic types of human papilloma virus (HPV). But only a small fraction of those infected develop cancer, indicating that other factors contribute to the progression to cervical cancer. We have compared incidence of the disease in relatives of cases of cervical tumour and controls, and find a significant familial clustering among biological, but not adoptive, relatives. We find no difference in the risk to siblings who have a mother or father in common, so the clustering cannot be explained by vertical transmission of HPV from mother to child. These results provide epidemiological evidence of a genetic predisposition to cervical cancer.</description><subject>Age of Onset</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Human papillomavirus</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Medicin och hälsovetenskap</subject><subject>multidisciplinary</subject><subject>Papillomaviridae</subject><subject>Papillomavirus Infections - transmission</subject><subject>Registries</subject><subject>Risk Assessment</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>scientific-correspondence</subject><subject>Sweden - epidemiology</subject><subject>Tumor Virus Infections - transmission</subject><subject>Uterine Cervical Neoplasms - epidemiology</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - virology</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkk9P3DAQxa2qVdkCn6BSFVVqewod2-M_OVaoQCWkXujZcrLjKpBNtnZCxbfHSxYWIQEnW57fe2N7HmOHHI44SPtdcAv8DVtwNLpEbc1btgAQtgQr9R77kNIlAChu8D3b44AgBeKCFafU09g2Rdf2V8U4FA3F67bxXTFOq2GK6YC9C75LdLhd99mfk58Xx2fl-e_TX8c_zstGSTmWRpAQFpUMKhDogESaDDV86VVlUQSUuoYQagkq1FWtZVXX1kv0trGVkXKflbNv-k_rqXbr2K58vHGDb9326CrvyGnAStrM22f5dRyWO9G9kCsrQWidpd9maeb-TZRGt2pTQ13nexqm5CwYoStr8VXS5FcZ5Nxk8uuL5MZPiqp6FeS5tzKCZ_DzE_Ayz6PPM3ACEI1C3Lh9maEmDilFCg__wMFtcuHucpG5T1uzqV7R8hE1B2F3rZRL_V-Ku25PnT7OYO_HKdKD01y9BXFdxQ4</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Magnusson, Patrik K. E</creator><creator>Sparén, Pär</creator><creator>Gyllensten, Ulf B</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7X8</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>BTSUP</scope></search><sort><creationdate>19990701</creationdate><title>Genetic link to cervical tumours</title><author>Magnusson, Patrik K. E ; Sparén, Pär ; Gyllensten, Ulf B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-72e228453f5fe06f4ee6e7ec1da59842f436b0ffb305fb9b639bb8a34a8c89733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Age of Onset</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Human papillomavirus</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Medicin och hälsovetenskap</topic><topic>multidisciplinary</topic><topic>Papillomaviridae</topic><topic>Papillomavirus Infections - transmission</topic><topic>Registries</topic><topic>Risk Assessment</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>scientific-correspondence</topic><topic>Sweden - epidemiology</topic><topic>Tumor Virus Infections - transmission</topic><topic>Uterine Cervical Neoplasms - epidemiology</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magnusson, Patrik K. E</creatorcontrib><creatorcontrib>Sparén, Pär</creatorcontrib><creatorcontrib>Gyllensten, Ulf B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest_Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials science collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Computer and Information Systems Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SwePub Editorial</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magnusson, Patrik K. E</au><au>Sparén, Pär</au><au>Gyllensten, Ulf B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic link to cervical tumours</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>400</volume><issue>6739</issue><spage>29</spage><epage>30</epage><pages>29-30</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Cervical cancer is strongly associated with infection by oncogenic types of human papilloma virus (HPV). But only a small fraction of those infected develop cancer, indicating that other factors contribute to the progression to cervical cancer. We have compared incidence of the disease in relatives of cases of cervical tumour and controls, and find a significant familial clustering among biological, but not adoptive, relatives. We find no difference in the risk to siblings who have a mother or father in common, so the clustering cannot be explained by vertical transmission of HPV from mother to child. These results provide epidemiological evidence of a genetic predisposition to cervical cancer.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>10403244</pmid><doi>10.1038/21801</doi><tpages>2</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0028-0836 |
ispartof | Nature (London), 1999-07, Vol.400 (6739), p.29-30 |
issn | 0028-0836 1476-4687 |
language | eng |
recordid | cdi_swepub_primary_oai_swepub_ki_se_604938 |
source | Nature |
subjects | Age of Onset Female Genetic Predisposition to Disease Human papillomavirus Humanities and Social Sciences Humans Infectious Disease Transmission, Vertical Medicin och hälsovetenskap multidisciplinary Papillomaviridae Papillomavirus Infections - transmission Registries Risk Assessment Science Science (multidisciplinary) scientific-correspondence Sweden - epidemiology Tumor Virus Infections - transmission Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology |
title | Genetic link to cervical tumours |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T05%3A33%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20link%20to%20cervical%20tumours&rft.jtitle=Nature%20(London)&rft.au=Magnusson,%20Patrik%20K.%20E&rft.date=1999-07-01&rft.volume=400&rft.issue=6739&rft.spage=29&rft.epage=30&rft.pages=29-30&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/21801&rft_dat=%3Cproquest_swepu%3E1241031851%3C/proquest_swepu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c533t-72e228453f5fe06f4ee6e7ec1da59842f436b0ffb305fb9b639bb8a34a8c89733%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=204475449&rft_id=info:pmid/10403244&rfr_iscdi=true |