CRBP I and CRABP I localisation during olfactory nerve development

Retinoic acid appears to play a role during the formation of the olfactory system. Immunohistochemistry was used to localise the cellular retinoid binding-proteins for retinol (CRBP I) and retinoic acid (CRABP I) in the embryonic and adult olfactory system. Our results indicate that RA produced by t...

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Bibliographic Details
Published in:Brain research. Developmental brain research 1999-04, Vol.114 (1), p.121-126
Main Authors: Gustafson, Anne-Lee, Eriksson, Ulf, Dencker, Lennart
Format: Article
Language:English
Subjects:
Animals
Axons - chemistry
CRABP I
CRBP I
Embryogenesis
Medicin och hälsovetenskap
Mice
Mice, Inbred C57BL
Mouse
Olfactory
Olfactory Bulb - chemistry
Olfactory Bulb - cytology
Olfactory Bulb - embryology
Olfactory Nerve - chemistry
Olfactory Nerve - cytology
Olfactory Nerve - embryology
Olfactory Receptor Neurons - chemistry
Olfactory Receptor Neurons - physiology
Olfactory Receptor Neurons - ultrastructure
Receptors, Retinoic Acid - analysis
Retinoic acid
Retinol-Binding Proteins - analysis
Retinol-Binding Proteins, Cellular
Tretinoin - physiology
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Summary:Retinoic acid appears to play a role during the formation of the olfactory system. Immunohistochemistry was used to localise the cellular retinoid binding-proteins for retinol (CRBP I) and retinoic acid (CRABP I) in the embryonic and adult olfactory system. Our results indicate that RA produced by the CRBP I-expressing `glia-like' cells may act as a neurotrophic factor for the CRABP I-expressing immature olfactory axons.
ISSN:0165-3806
DOI:10.1016/S0165-3806(99)00014-0