Ultra low concentrated molecular detection using super hydrophobic surface based biophotonic devices

Micro and nano-patterned devices were fabricated which disclose the possibility of concentrating, localizing, detecting and thus analyzing with unprecedented accuracy few molecules (at the limit a single molecule) of biological and medical interest. Important applications are envisioned where protei...

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Bibliographic Details
Published in:Microelectronic engineering 2010-05, Vol.87 (5), p.798-801
Main Authors: Gentile, F., Das, G., Coluccio, M.L., Mecarini, F., Accardo, A., Tirinato, L., Tallerico, R., Cojoc, G., Liberale, C., Candeloro, P., Decuzzi, P., De Angelis, F., Di Fabrizio, E.
Format: Article
Language:English
Subjects:
Applied sciences
Biophotonics and plasmonics
Blood
Cancer
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Cross-disciplinary physics: materials science
rheology
Devices
Dilution
Early detection
Electronics
Exact sciences and technology
Materials science
Medicin och hälsovetenskap
Methods of nanofabrication
Microelectronic fabrication (materials and surfaces technology)
Molecular electronics, nanoelectronics
Nano-optics
Nanocomposites
Nanomaterials
Nanoscale pattern formation
Nanostructure
Optical properties and condensed-matter spectroscopy and other interactions of matter with particles and radiation
Photoluminescence
Physics
Semiconductor electronics. Microelectronics. Optoelectronics. Solid state devices
Spectroscopy
Super hydrophobic surfaces
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Summary:Micro and nano-patterned devices were fabricated which disclose the possibility of concentrating, localizing, detecting and thus analyzing with unprecedented accuracy few molecules (at the limit a single molecule) of biological and medical interest. Important applications are envisioned where proteins poorly concentrated in blood are detected thus (early) revealing the appearance of diseases. The major advance of the paper is that it combines micro/nano-fabrication and spectroscopical nano-optics based techniques to study and individualize the biomolecules at study. Super hydrophobic surface would concentrate the diluted solution into a small area whereas spectroscopical nano-optics techniques would gather the molecular/chemical information of the residual solute. Fluorescence and SERS techniques were used to analyze Rhodamine molecules initially highly diluted (10 −18 M).
ISSN:0167-9317
1873-5568
DOI:10.1016/j.mee.2009.11.083