Synthesis of Metabolites of the Ah Receptor Ligand 6-Formylindolo[3,2-b]carbazole

Synthesis of the five mono‐ and di‐hydroxylated metabolites of the aryl hydrocarbon receptor high affinity ligand 6‐formylindolo[3,2‐b]carbazole is described. The structures of the metabolites were unequivocally established as 2‐hydroxy‐, 8‐hydroxy‐, 2,10‐dihydroxy‐, 4,8‐dihydroxy‐ and 2,8‐dihydroxy...

Full description

Saved in:
Bibliographic Details
Published in:European journal of organic chemistry 2004-06, Vol.2004 (12), p.2593-2602
Main Authors: Wahlström, Niklas, Romero, Ivan, Bergman, Jan
Format: Article
Language:English
Subjects:
2-b]carbazole
6-Formylindolo
6‐Formylindolo[3,2‐b]carbazole
Acylations
Ah receptor
Bis(indoles)
Metabolite
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Synthesis of the five mono‐ and di‐hydroxylated metabolites of the aryl hydrocarbon receptor high affinity ligand 6‐formylindolo[3,2‐b]carbazole is described. The structures of the metabolites were unequivocally established as 2‐hydroxy‐, 8‐hydroxy‐, 2,10‐dihydroxy‐, 4,8‐dihydroxy‐ and 2,8‐dihydroxyindolo[3,2‐b]carbazole‐6‐carboxaldehyde. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
ISSN:1434-193X
1099-0690
1099-0690
DOI:10.1002/ejoc.200400087