Synthetic applications of 3-(cyanoacetyl)indoles and related compounds

Various synthetic applications of 3‐(cyanoacetyl)indoles, as well as syntheses of some related indoles, have been investigated. Diethyl 2‐(1H‐indol‐3‐yl)‐2‐oxoethylphosphonate and a methyl derivative thereof have been prepared in one step from indole. Moreover, it was demonstrated that 3‐(cyanoacety...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2005-01, Vol.42 (1), p.141-145
Main Authors: Slätt, Johnny, Janosik, Tomasz, Wahlström, Niklas, Bergman, Jan
Format: Article
Language:English
Subjects:
cyanoacetylindole prepn reaction
Medicin och hälsovetenskap
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Summary:Various synthetic applications of 3‐(cyanoacetyl)indoles, as well as syntheses of some related indoles, have been investigated. Diethyl 2‐(1H‐indol‐3‐yl)‐2‐oxoethylphosphonate and a methyl derivative thereof have been prepared in one step from indole. Moreover, it was demonstrated that 3‐(cyanoacetyl)indoles are useful starting materials for the preparation of for example 3‐(1H‐indol‐3‐yl)‐3‐oxopropanamides, 3‐heteroarylindoles or 3‐heteroaroylindoles.
ISSN:0022-152X
1943-5193
1943-5193
DOI:10.1002/jhet.5570420122