Bone fragility and osteoporosis in children and young adults

Osteoporosis is a metabolic bone disorder which increases fragility fracture risk. Elderly individuals, especially postmenopausal women, are particularly susceptible to osteoporosis. Although rare, osteoporosis in children and young adults is becoming increasingly evident, highlighting the need for...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2024, Vol.47 (2), p.285-298
Main Authors: Formosa, M. M., Christou, M. A., Mäkitie, O.
Format: Article
Language:English
Subjects:
Actin
Age
Biopsy
Children
Collagen (type I)
Comorbidity
Endocrinology
Fractures
Genetic screening
Internal Medicine
LRP5 protein
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Metabolic Diseases
Molecular modelling
Osteoporosis
Post-menopause
Radiography
Regulatory proteins
Short Review
Signal transduction
Sphingomyelin
Vertebrae
Wnt protein
Young adults
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Summary:Osteoporosis is a metabolic bone disorder which increases fragility fracture risk. Elderly individuals, especially postmenopausal women, are particularly susceptible to osteoporosis. Although rare, osteoporosis in children and young adults is becoming increasingly evident, highlighting the need for timely diagnosis, management and follow-up. Early-onset osteoporosis is defined as the presence of a low BMD (Z-score of ≤ −2.0 in individuals aged 
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-023-02179-0