Albumin and fibrinogen synthesis rates in advanced chronic liver disease

• Published in: American journal of physiology: Gastrointestinal and liver physiology 2023-11, Vol.325 (5), p.G391-G397
• Main Authors: Amouzandeh, Mariam, Sundström, Anna, Wahlin, Staffan, Wernerman, Jan, Rooyackers, Olav, Norberg, Åke
• Format: Article
• Language: English
• Subjects: Fibrinogen; Human serum albumin; Inflammation; Liver diseases; Liver transplantation; Medicin och hälsovetenskap; Plasma; Plasma proteins
• ISSN: 0193-1857; 1522-1547; 1522-1547
• DOI: 10.1152/ajpgi.00072.2023

Albumin and fibrinogen synthesis were positively correlated, but the high variation indicates that these are probably influenced by different mechanisms. There might be a limited metabolic reserve for the liver to increase both albumin and fibrinogen synthesis in response to longstanding inflammation in CLD and fibrinogen seems to be prioritized. Synthesis of plasma proteins is an important function of the liver that has sparsely been investigated by modern techniques in patients with advanced chronic liver disease (CLD). Twenty-eight well-characterized patients with CLD under evaluation for liver transplantation were included. Albumin and fibrinogen synthesis rates were measured by the flooding dose technique using stable isotope-labeled phenylalanine. Transcapillary escape rate of albumin and plasma volume were assessed by radioiodinated human serum albumin. The absolute albumin synthesis rates were low (65 mg/kg/day, range: 32–203) and were associated with impaired liver function, as reflected by the risk-scores Child-Pugh ( P = 0.025) and model for end-stage liver disease ( rs = −0.62, P = 0.0005). The fibrinogen synthesis rate (12.8 mg/kg/day, range: 2.4–52.9) was also negatively associated with liver function. The synthesis rates of albumin and fibrinogen were positively correlated. Plasma volume was high (51 ± 9 mL/kg body wt), which contributed to an almost normal intravascular albumin mass despite low plasma concentration. Autoimmune inflammatory etiologies to CLD were associated with higher fibrinogen synthesis. De novo synthesis rates of albumin and fibrinogen in advanced chronic liver failure were negatively correlated to prognostic scores of liver disease. Albumin synthesis rate was low and associated with both liver failure and autoimmune inflammation, whereas fibrinogen synthesis was often normal and positively associated with chronic inflammation. This is different from acute inflammatory states in which both albumin and fibrinogen synthesis rates are high. NEW & NOTEWORTHY Albumin and fibrinogen synthesis were positively correlated, but the high variation indicates that these are probably influenced by different mechanisms. There might be a limited metabolic reserve for the liver to increase both albumin and fibrinogen synthesis in response to longstanding inflammation in CLD and fibrinogen seems to be prioritized.