Aggressive B-cell non-Hodgkin lymphomas: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology

Aggressive B-cell non-Hodgkin lymphomas are a heterogeneous group of diseases and our concepts are evolving as we learn more about their clinical, pathologic, molecular genetic features. Session IV of the 2020 EAHP Workshop covered aggressive, predominantly high-grade B-cell lymphomas, many that wer...

Full description

Saved in:
Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2024-01, Vol.484 (1), p.15-29
Main Authors: Rodriguez-Pinilla, Socorro Maria, Dojcinov, Stefan, Dotlic, Snjezana, Gibson, Sarah E., Hartmann, Sylvia, Klimkowska, Monika, Sabattini, Elena, Tousseyn, Thomas A., de Jong, Daphne, Hsi, Eric. D.
Format: Article
Language:English
Subjects:
Adult
B-cell lymphoma
Bcl-2 protein
Bcl-6 protein
Burkitt Lymphoma - genetics
Burkitt's lymphoma
Cellular biology
Chromosome Aberrations
Classification
DNA nucleotidylexotransferase
Gene Rearrangement
Humans
Interferon regulatory factor 4
Lymphocytes B
Lymphoma
Lymphoma, Large B-Cell, Diffuse - pathology
Lymphoma, Mantle-Cell - genetics
Mantle cell lymphoma
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Morphology
Myc protein
Pathology
Phenotype
Proto-Oncogene Proteins c-bcl-2 - genetics
Proto-Oncogene Proteins c-myc - genetics
Review and Perspectives
Review and s
Terminology
Workshops
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aggressive B-cell non-Hodgkin lymphomas are a heterogeneous group of diseases and our concepts are evolving as we learn more about their clinical, pathologic, molecular genetic features. Session IV of the 2020 EAHP Workshop covered aggressive, predominantly high-grade B-cell lymphomas, many that were difficult to classify. In this manuscript, we summarize the features of the submitted cases and highlight differential diagnostic difficulties. We specifically review issues related to high-grade B-cell lymphomas (HGBCLs) with MYC and BCL2 and/or BCL6 rearrangements including TdT expression in these cases, HGBCL, not otherwise specified, large B-cell lymphomas with IRF4 rearrangement, high-grade/large B-cell lymphomas with 11q aberration, Burkitt lymphoma, and pleomorphic mantle cell lymphoma. Since the workshop, the 5th edition of the WHO Classification for Haematolymphoid Tumours (WHO-HAEM5) and International Consensus Classification (ICC) 2022 were published. We endeavor to use the updated terminology.
ISSN:0945-6317
1432-2307
1432-2307
DOI:10.1007/s00428-023-03579-6