Loading…

Lower complement C1q levels in first-episode psychosis and in schizophrenia

[Display omitted] •C1QA expression is reduced in prefrontal cortex tissue of individuals with schizophrenia.•C1QA brain co-expression networks do not exhibit genetic enrichment for schizophrenia independent of C4A.•Already during the first acute psychotic episode, cerebrospinal fluid C1qA protein le...

Full description

Saved in:
Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2024-03, Vol.117, p.313-319
Main Authors: Koskuvi, Marja, Malwade, Susmita, Gracias Lekander, Jessica, Hörbeck, Elin, Bruno, Sanna, Holmen Larsson, Jessica, Pelanis, Aurimantas, Isgren, Anniella, Goulding, Anneli, Fatouros-Bergman, Helena, Samudyata, Schalling, Martin, Piehl, Fredrik, Erhardt, Sophie, Landen, Mikael, Cervenka, Simon, Orhan, Funda, Sellgren, Carl M.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •C1QA expression is reduced in prefrontal cortex tissue of individuals with schizophrenia.•C1QA brain co-expression networks do not exhibit genetic enrichment for schizophrenia independent of C4A.•Already during the first acute psychotic episode, cerebrospinal fluid C1qA protein levels are reduced in schizophrenia. Recent evidence has implicated complement component (C) 4A in excessive elimination of synapses in schizophrenia. C4A is believed to contribute to physiological synapse removal through signaling within the C1q initiated classical activation axis of the complement system. So far, a potential involvement of C1q in the pathophysiology of schizophrenia remains unclear. In this study, we first utilized large-scale gene expression datasets (n = 586 patients with schizophrenia and n = 986 controls) to observe lower C1QA mRNA expression in prefrontal cortex tissue of individuals with schizophrenia (P = 4.8x10-05), while C1QA seeded co-expression networks displayed no enrichment for schizophrenia risk variants beyond C4A. We then used targeted liquid chromatography-mass spectrometry (LS-MS) to measure cerebrospinal fluid (CSF) levels of C1qA in 113 individuals with first-episode psychosis (FEP), among which 66 individuals was later diagnosed with schizophrenia, and 87 healthy controls. CSF concentrations of C1qA were lower in individuals diagnosed with FEP (P = 0.0001), also after removing subjects with a short-term prescription of an antipsychotic agent (P = 0.0005). We conclude that C1q mRNA and protein levels are lower in schizophrenia and that further experimental studies are needed to understand the functional implications.
ISSN:0889-1591
1090-2139
1090-2139
DOI:10.1016/j.bbi.2024.01.219