Navigating the blurred path of mixed neuroimmune signaling

Evolution has created complex mechanisms to sense environmental danger and protect tissues, with the nervous and immune systems playing pivotal roles. These systems work together, coordinating local and systemic reflexes to restore homeostasis in response to tissue injury and infection. By sharing r...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2024-04, Vol.153 (4), p.924-938
Main Authors: Gupta, Surbhi, Viotti, Alice, Eichwald, Tuany, Roger, Anais, Kaufmann, Eva, Othman, Rahmeh, Ghasemlou, Nader, Rafei, Moutih, Foster, Simmie L., Talbot, Sebastien
Format: Article
Language:English
Subjects:
allergy
asthma
CGRP
cytokines
ILC2
neuroimmunology
neuropeptides
Nociceptor neurons
pain
psoriasis
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Summary:Evolution has created complex mechanisms to sense environmental danger and protect tissues, with the nervous and immune systems playing pivotal roles. These systems work together, coordinating local and systemic reflexes to restore homeostasis in response to tissue injury and infection. By sharing receptors and ligands, they influence the pathogenesis of various diseases. Recently, a less-explored aspect of neuroimmune communication has emerged: the release of neuropeptides from immune cells and cytokines/chemokines from sensory neurons. This article reviews evidence of this unique neuroimmune interplay and its impact on the development of allergy, inflammation, itch, and pain. We highlight the effects of this neuroimmune signaling on vital processes such as host defense, tissue repair, and inflammation resolution, providing avenues for exploration of the underlying mechanisms and therapeutic potential of this signaling.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2024.02.006